Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

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dc.contributor.authorKocaman, Gulhan
dc.contributor.authorOrbak, Recep
dc.date.accessioned2024-09-29T16:06:08Z
dc.date.available2024-09-29T16:06:08Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: This case control study examined the frequency and distribution of the C677T and A1298C single-nucleotide polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene in Turkish patients with chronic periodontitis. Materials and Methods: This study included 89 subjects: 49 patients with chronic periodontitis and 40 healthy persons. Medical and periodontal histories were taken, and PD, CAL, PI, and BOP were recorded as the clinical parameters. The blood samples were taken from the subjects, and their DNA was obtained. The MTHFR gene's single nucleotide polymorphisms 677C -> T and 1298A -> C genotyping were analyzed using the RFLP assay, then PCR. Results: There was a significant difference between the groups except for age when the clinical findings. Single-nucleotide polymorphisms in the MTHFR gene C677T and 1298C regions were not found to be significantly different between the groups. Conclusion: The study revealed no association between the MTHFR polymorphism and the risk of chronic periodontitis; however, increasing the number of patients is useful when performing further studies. This present study is important because it is, to the best of our knowledge, the first study to research the interrelation between the MTHFR gene and chronic periodontitis.en_US
dc.description.sponsorshipAtaturk University [2009/325]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinator of Ataturk University with the BAP project number 2009/325, and it was produced from a PhD thesis.en_US
dc.identifier.doi10.14744/etd.2019.39259
dc.identifier.endpage254en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue3en_US
dc.identifier.startpage250en_US
dc.identifier.trdizinid320081en_US
dc.identifier.urihttps://doi.org/10.14744/etd.2019.39259
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/320081
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6654
dc.identifier.volume41en_US
dc.identifier.wosWOS:000485683800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethylenetetrahydrofolate reductase (MTHFR)en_US
dc.subjectpolymorphismsen_US
dc.subjectperiodontitisen_US
dc.titleInvestigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitisen_US
dc.typeArticleen_US

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