Synthesis and characterization of novel triazol compounds containing a thiophen ring as potential antifungal agents and the structure of 2-(2-hydroxy-2-p-tolyethyl)-5-(thiophen-2-ylmethyl)-4- (4h-1,2,4-triazol-4-yl)-2h-1,2,4-triazol-3(4h)-one

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dc.contributor.authorÜnver, Yasemin
dc.contributor.authorDügdü, Esra
dc.contributor.authorSancak, Kemal
dc.contributor.authorEr, Mustafa
dc.contributor.authorUstabaş, Reşat
dc.date.accessioned2024-09-29T16:35:24Z
dc.date.available2024-09-29T16:35:24Z
dc.date.issued2010
dc.departmentKarabük Üniversitesien_US
dc.description.abstractA series of new 4-(3,5-disubstitue-4H-1,2,4-triazol-4-yl)-5-(thiophen-2-yl-methyl)-2H-1,2,4-triazol-3(4H)- ones (3a-c) were obtained by reaction N’-1-ethoxy-2-thiophen-2-yl-ethylydene hydrazino carboxylic acid ethyl ester (1) and 4-amino-4H-1,2,4-triazoles (2). 4-(3,5-disubstitue-4H-1,2,4-triazol-4-yl)-2-(2-oxo-2-arylethyl)- 5-(thiophen-2-yl-methyl)-2H-1,2,4-triazol-3(4H)-ones (4a-e) and ethyl 2-(4-(3,5-disubstitue-4H-1,2,4-triazol- 4-yl)-5-oxo-3-(thiophen-2-ylmethyl)-4,5-dihydro-1,2,4-triazol-1-yl)acetates (6a-c) were obtained by reaction of compounds 3 and bromoacetophenon derivatives and bromo ethylacetate, respectively. Compounds 5a-e were synthesized from the reaction of corresponding compounds 4a-e with NaBH4 . Compounds 7a-c were obtained by the reaction compounds 6 and LiAlH4 . Seventeen new compounds were synthesized and characterized by elemental analyses, IR, $^1 H-$NMR, and $^{13}C$-NMR spectral data. The structure of compound 5d was inferred through IR, $^1 H-, ^{13}C-NMR$, elemental analyses, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antibacterial and antifungal properties. Among the chemicals tested, 6a and 6b exhibited the highest degree of antifungal activity.en_US
dc.identifier.endpage563en_US
dc.identifier.issn1300-0527
dc.identifier.issue4en_US
dc.identifier.startpage551en_US
dc.identifier.trdizinid104331en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/104331
dc.identifier.urihttps://hdl.handle.net/20.500.14619/12727
dc.identifier.volume34en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMühendisliken_US
dc.subjectKimyaen_US
dc.titleSynthesis and characterization of novel triazol compounds containing a thiophen ring as potential antifungal agents and the structure of 2-(2-hydroxy-2-p-tolyethyl)-5-(thiophen-2-ylmethyl)-4- (4h-1,2,4-triazol-4-yl)-2h-1,2,4-triazol-3(4h)-oneen_US
dc.typeArticleen_US

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