Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms

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dc.authoridNurnberger, John/0000-0002-7674-1767
dc.authoridChartier, Karen/0000-0002-2410-2584
dc.authoridBucholz, Kathleen/0000-0003-3794-0736
dc.contributor.authorChartier, Karen G.
dc.contributor.authorDick, Danielle M.
dc.contributor.authorAlmasy, Laura
dc.contributor.authorChan, Grace
dc.contributor.authorAliev, Fazil
dc.contributor.authorSchuckit, Marc A.
dc.contributor.authorScott, Denise M.
dc.date.accessioned2024-09-29T16:11:28Z
dc.date.available2024-09-29T16:11:28Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption related phenotypes. Method: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1B-rs1229984, ADHIB-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance. Results: Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement. Conclusions: This study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism (NIAAA) [K01AA021145, K02AA018755]; National Institutes of Health (NIH) from the NIAAA [U10AA008401]; National Institute on Drug Abuse (NIDA); National Cancer Institute Cancer Center [P30 CA91842]; ICTS/CTSA Grant from the National Center for Research Resources, a component of the NIH [UL1RR024992]; NIH Roadmap for Medical Research; NIAAA; NIH GEI [U01HG004438]; NIH [HHSN268200782096C]en_US
dc.description.sponsorshipResearch reported in this publication was supported by National Institute on Alcohol Abuse and Alcoholism (NIAAA) award numbers K01AA021145 (to Karen G. Chartier, principal investigator) and K02AA018755 (to Danielle M. Dick, principal investigator). This national collaborative study is supported by National Institutes of Health (NIH) Grant U10AA008401 from the NIAAA and the National Institute on Drug Abuse (NIDA). The Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine is partially supported by National Cancer Institute Cancer Center Support Grant #P30 CA91842 to the Siteman Cancer Center and by ICTS/CTSA Grant #UL1RR024992 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research. Funding support for Genome-Wide Association Study genotyping, which was performed at The Johns Hopkins University Center for Inherited Disease Research, was provided by the NIAAA, the NIH GEI (U01HG004438), and the NIH contract High throughput genotyping for studying the genetic contributions to human disease (HHSN268200782096C). This article was originally presented as a poster at the World Congress of Psychiatric Genetics.en_US
dc.identifier.endpage404en_US
dc.identifier.issn1937-1888
dc.identifier.issn1938-4114
dc.identifier.issue3en_US
dc.identifier.pmid27172571en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8464
dc.identifier.volume77en_US
dc.identifier.wosWOS:000375969500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAlcohol Res Documentation Inc Cent Alcohol Stud Rutgers Univen_US
dc.relation.ispartofJournal of Studies On Alcohol and Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnvironment Interactionen_US
dc.subjectSubstance Useen_US
dc.subjectEuropean-Americansen_US
dc.subjectChurch Attendanceen_US
dc.subjectDrug-Dependenceen_US
dc.subjectRisken_US
dc.subjectLinkageen_US
dc.subjectConsumptionen_US
dc.subjectPhenotypesen_US
dc.subjectAdh1ben_US
dc.titleInteractions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptomsen_US
dc.typeArticleen_US

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