The effect of proliferative hypertrophic scars on determining treatment options for preventing recurrence of vesicourethral anastomotic stenosis after radical prostatectomy: a single-center cross-sectional study

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dc.authoridSELVI, ISMAIL/0000-0003-3578-0732
dc.authoridBasar, Halil/0000-0003-1770-5165
dc.contributor.authorSelvi, Ismail
dc.contributor.authorArik, Ali Ihsan
dc.contributor.authorBasay, Mehmet Sinan
dc.contributor.authorBasar, Halil
dc.date.accessioned2024-09-29T16:06:22Z
dc.date.available2024-09-29T16:06:22Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBACKGROUND: Vesicourethral anastomotic stenosis (VUAS) following retropubic radical prostatectomy (RRP) significantly worsens quality of life. OBJECTIVES: To investigate the relationship between proliferative hypertrophic scar formation and VUAS, and predict more appropriate surgical intervention for preventing recurrent VUAS. DESIGN AND SETTING: Retrospective cross-sectional single-center study on data covering January 2009 to December 2019. METHODS: Among 573 male patients who underwent RRP due to prostate cancer, 80 with VUAS were included. They were divided into two groups according to VUAS treatment method: dilatation using Amplatz renal dilators (39 patients); or endoscopic bladder neck incision/resection (41 patients). The Vancouver scar scale (VSS) was used to evaluate the characteristics of scars that occurred for any reason before development of VUAS. RESULTS: Over a median follow-up of 72 months (range 12-105) after RRP, 17 patients (21.3%) had recurrence of VUAS. Although the treatment success rates were similar (79.5% versus 78.0%; P = 0.875), receiver operating characteristic (ROC) curve analysis indicated that dilatation using Amplatz dilators rather than endoscopic bladder neck incision/resection in patients with VSS scores 4, 5 and 6 may significantly reduce VUAS recurrence. A strong positive relationship was observed between VSS and total number of VUAS occurrences (r: 0.689; P < 0.001). VSS score (odds ratio, OR: 5.380; P < 0.001) and time until occurrence of VUAS (OR: 1.628; P = 0.008) were the most significant predictors for VUAS recurrence. CONCLUSIONS: VSS score can be used as a prediction tool for choosing more appropriate surgical intervention, for preventing recurrent VUAS.en_US
dc.identifier.doi10.1590/1516-3180.2020.0349.R1.28012021
dc.identifier.endpage250en_US
dc.identifier.issn1516-3180
dc.identifier.issue3en_US
dc.identifier.pmid33909829en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1590/1516-3180.2020.0349.R1.28012021
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6799
dc.identifier.volume139en_US
dc.identifier.wosWOS:000659295300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssociacao Paulista Medicinaen_US
dc.relation.ispartofSao Paulo Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrinary bladder neck obstructionen_US
dc.subjectProstatectomyen_US
dc.subjectCicatrix hypertrophicen_US
dc.titleThe effect of proliferative hypertrophic scars on determining treatment options for preventing recurrence of vesicourethral anastomotic stenosis after radical prostatectomy: a single-center cross-sectional studyen_US
dc.typeArticleen_US

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