Comparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy

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dc.authoridhttps://orcid.org/0000-0002-9777-5173
dc.authoridhttps://orcid.org/0000-0002-1670-696X
dc.authoridhttps://orcid.org/0000-0003-2477-074X
dc.contributor.authorGurbuz Can, Venhar
dc.contributor.authorCesur Gunay, Ozlem
dc.contributor.authorCesur, Sinem
dc.date.accessioned2025-01-06T07:45:52Z
dc.date.available2025-01-06T07:45:52Z
dc.date.issued2024-12-30
dc.departmentFakülteler, Tıp Fakültesi, Acil Tıp Bilimleri Bölümü
dc.description.abstractType 2 diabetes (T2DM) is a group of chronic and systemic metabolic diseases. Nephropathy (NP) and neuropathy (NR) are two common complications that severely affect the quality of life of patients with T2DM. In this study, our aim was to investigate the association between TNF-alpha (-308) gene polymorphism and the risk of developing NP and NR in patients with T2DM We also aimed to determine the association between TNF-alpha (-308) gene polymorphism and several demographic characteristics and biochemical parameters of patients with T2DM developed NP and/or NR. First, blood samples of patients were collected, and DNA isolation was performed. Then, real-time PCR analysis was used for genotyping the TNF-α (-308) gene utilising fluorescently labelled probes. Patients’ demographical data and biochemical parameters were also obtained. Our study did not detect any significant difference in the frequency of possessing the gene polymorphism (A allele) between the groups. Additionally, no significant difference was detected when the data on various biochemical parameters were evaluated in GG, GA, and AA genotypes.
dc.identifier.citationCan, V. G., Gunay, O. C., & Cesur, S. (2024). Comparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy. Scientific reports, 14(1), 31731. https://doi.org/10.1038/s41598-024-82773-1
dc.identifier.doi10.1038/s41598-024-82773-1
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid39738562
dc.identifier.scopus2-s2.0-85213727214
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-024-82773-1
dc.identifier.urihttps://hdl.handle.net/20.500.14619/14948
dc.identifier.volume14
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA polymorphism
dc.subjectNephropathy
dc.subjectNeuropathy
dc.subjectTNF-α
dc.subjectType 2 diabetes
dc.titleComparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy
dc.typeArticle
oaire.citation.issue1
oaire.citation.volume14

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