Reduced levels of circulating natural killer cells in children with celiac disease

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dc.contributor.authorAgin, Mehmet
dc.contributor.authorSevinc, Eylem
dc.contributor.authorDogan, Erkan
dc.contributor.authorSevinc, Nergiz
dc.date.accessioned2024-09-29T16:12:17Z
dc.date.available2024-09-29T16:12:17Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground Celiac disease (CD) is an autoimmune disease characterized by malabsorption. Serologic testing for CD consists of Ig A type of antitissue transglutaminase (tTG), antiendomysium (EMA). These tests are helpful in monitoring adherence to the gluten-free diet (GFD). Natural killer (NK) cell count alterations have been reported in various diseases, such as cancer, Crohn's disease, malnutrition, and autoimmune disorders. Objective To compare peripheral blood NK cell counts in children with celiac disease (CD) to healthy controls. The second aim was to analyze for possible correlations between NK cells (CD3-/CD16+, CD56+) and tissue transglutaminase (tTG)- IgA and tTG-IgG, as well as endomysial antibody EMA-IgA indicating. gluten sensitivity. Methods Fifty children with CD were compared to 48 healthy children as controls, with similar age and sex distribution. Peripheral blood NK cell counts were measured by flow cytometry. Results The median (P25-P75) ages of the 50 celiac patients (23 male; 46%) and 48 controls (21 male; 44%) were 10 (2-17) years and 9 (3-17) years, respectively. Mean follow-up duration was 3 years, ranging from 1-10 years. All CD patients had positive tTG-IgA and EMA-IgA tests. while it was negative in all (100 %) control patients. The absolute number of circulating CD16+ NK cells (259.52 vs. 1404.36 mu/L) and CD56 + NK cells (366.24 vs. 2440.46 mu/L) were significantly lower in the celiac group than the control group (P<0.05 for both). The absolute numbers of circulating white blood cells (7785 vs. 8165 mu/L) and lymphocytes (3106 vs. 3173 mu/L) were not significantly different between the celiac and control groups (P>0.05 for both). Correlation analysis between the absolute number of circulating NK cells and tTG-IgA, tTG-IgG, and EMA-IgA levels in CD patients revealed no significant relationships (P>0.05 for all). Conclusions Peripheral blood NK cell count are significantly lower in celiac patients than controls, hence, decreased NK cell counts may be an abnormal feature seen in autoimmune diseases. NK cell count in celiac patients has no significant correlations to tTG-IgA, tTG-IgG, or EMA-IgA levels. Therefore, NK cell count may be inappropriate marker for monitoring compliance to a gluten free diet.en_US
dc.identifier.endpage129en_US
dc.identifier.issn0030-9311
dc.identifier.issn2338-476X
dc.identifier.issue3en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8652
dc.identifier.volume60en_US
dc.identifier.wosWOS:000542781400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIndonesian Pediatric Soc Publishing Houseen_US
dc.relation.ispartofPaediatrica Indonesianaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectceliac diseaseen_US
dc.subjectnatural killer cellsen_US
dc.titleReduced levels of circulating natural killer cells in children with celiac diseaseen_US
dc.typeArticleen_US

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