Morphometric alteration induced by cyclophosphamide in rat kidney and protective efficacy of coenzyme q10: a stereological study

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dc.contributor.authorYahyazadeh, Ahmad
dc.date.accessioned2024-09-29T16:32:07Z
dc.date.available2024-09-29T16:32:07Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractCyclophosphamide (CD), as a chemotherapeutic drug, is used for the elimination of cancer cells, but its toxicity has led to health problems. We aimed to investigate the efficacy of coenzyme Q10 (C10) on kidney alterations caused by CD treatment in Wistar albino rats. Thirty-five adult male rats were assigned into five groups: control (CO), olive oil (OO), CD, C10, and CD+C10. All kidney tissues were analysed using the stereological and histopathological techniques. Stereological results revealed that the mean volumes of kidney, cortex, medulla, and glomerulus were significantly increased in the CD group than the CO group (p < 0.05). We also observed a significant decrease in the mean volume of proximal tubules in the CD group than the CO group (p < 0.05). In the CD+C10 group, the mean volumes of kidney, cortex, medulla, and glomerulus were significantly less when compared to the CD group (p < 0.05). In addition, there was a significant increase in the mean volume of proximal tubules in the CD+C10 group than the CD group (p < 0.05). Histopathological examination also revealed valuable results. Our findings showed that treatment with CD caused destructive change in the rat kidney tissues. Moreover, C10 administration significantly attenuated the toxic effect of CD on the kidneys.en_US
dc.identifier.doi10.5455/medscience.2021.03.099
dc.identifier.endpage1127en_US
dc.identifier.issue4en_US
dc.identifier.startpage1122en_US
dc.identifier.trdizinid504455en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2021.03.099
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/504455
dc.identifier.urihttps://hdl.handle.net/20.500.14619/11369
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYahyazadeh, Ahmad
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleMorphometric alteration induced by cyclophosphamide in rat kidney and protective efficacy of coenzyme q10: a stereological studyen_US
dc.typeArticleen_US

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