Prognostic value of soluble factors of angiogenesis and adhesion processes in head and neck squamous cell carcinomas

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dc.authoridDERE, HACI HUSEYIN/0000-0003-0750-9590
dc.contributor.authorGun, Taylan
dc.contributor.authorIkinciogullari, Aykut
dc.contributor.authorBoztepe, Osman Fatih
dc.contributor.authorEnsari, Serdar
dc.contributor.authorDere, Huseyin
dc.date.accessioned2024-09-29T16:09:35Z
dc.date.available2024-09-29T16:09:35Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: In this study, we aimed to define the prognostic value of two factors related to angiogenesis and adhesion processes of head and neck squamous cell carcinomas. The prominent angiogenesis molecule is vascular endothelial growth factor (VEGF). The vascular cell adhesion molecule (VCAM) first attracted attention more than two decades ago as endothelial adhesion receptor with key function for leukocyte recruitment in term of cellular immune response. Material and Method: 35 patients with head and neck squamous cell carcinomas were enrolled in this study. The control group consisted of 20 people who had no sign of regional or systemic diseases. 33 patients were male and 2 patients were female. Mean age was 59.7 years (28-76). Results: We showed that VEGF levels in the patient group were significantly higher than in the control group (p=0.001). However, when comparing the VEGF levels of different stages, there was no statistical significant difference between the stages. Discussion: Serum VEGF levels can provide sufficient information for the early diagnosis of the disease but prognosis may not be evaluated according to the results of our study. VCAM levels were not specific and sensitive to use as a tumor marker but VCAM may be a valuable factor to determine the prognosis and tumor aggression in cancer patients.en_US
dc.identifier.doi10.4328/JCAM.5788
dc.identifier.endpage424en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue5en_US
dc.identifier.startpage421en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.5788
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7653
dc.identifier.volume9en_US
dc.identifier.wosWOS:000435652100013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVascular Cell Adhesion Moleculeen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectPrognosisen_US
dc.titlePrognostic value of soluble factors of angiogenesis and adhesion processes in head and neck squamous cell carcinomasen_US
dc.typeArticleen_US

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