Crocin (active constituent of saffron) improves ccl4-induced liver damage by modulating oxidative stress in rats

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dc.contributor.authorCosgun, Binnaz Elif
dc.contributor.authorErdemlı, Mehmet Erman
dc.contributor.authorGül, Mehmet
dc.contributor.authorGül, Semir
dc.contributor.authorGözükara Bağ, Harika Gözde
dc.contributor.authorErdemlı, Zeynep
dc.contributor.authorAltınöz, Eyüp
dc.date.accessioned2024-09-29T16:33:19Z
dc.date.available2024-09-29T16:33:19Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: CCl4 is a widely used xenobiotic for thepurpose of causing liver damage in experimental studies.In this study, we aimed to reveal the effects of crocin onliver injury caused by CCl4 via free radical scavengingproperties.Materials and methods: Animals were divided into fivegroups of 10: control; corn oil; crocin; CCl4; CCl4 + crocin.Tissue samples were carefully removed and separated forbiochemical and histological investigations.Results: CCl4 administration led to significant increases inMDA, SOD, CAT and TOS in liver tissue, and AST, ALT andALP levels in plasma (p < 0.05). In addition, CCl4 causedsignificant decreases in GSH and TAS (p < 0.05). Whenanimals were treated with crocin, high MDA, SOD, CAT,TOS levels, and AST and ALP activities decreased and GSHand TAS levels increased. Control group exhibited normalhistological appearance; however extensive necrosisareas were detected in the CCl4 group. In the CCl4 + crocingroup, pathological changes were markedly decreasedand the appearance of liver tissue was almost similar tothe control groups.Conclusion: Our results showed that crocin suppressesoxidative stress with antioxidant properties and has a protectiveeffect on tissue damage caused by CCl4.en_US
dc.identifier.endpage378en_US
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.startpage370en_US
dc.identifier.trdizinid335443en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/335443
dc.identifier.urihttps://hdl.handle.net/20.500.14619/11786
dc.identifier.volume44en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTürk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiş Hekimliğien_US
dc.subjectToksikolojien_US
dc.subjectBiyokimya ve Moleküler Biyolojien_US
dc.subjectFarmakoloji ve Eczacılıken_US
dc.titleCrocin (active constituent of saffron) improves ccl4-induced liver damage by modulating oxidative stress in ratsen_US
dc.typeArticleen_US

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