Efficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effects

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dc.authoridCebi, Ahmet Taylan/0000-0001-9083-7215
dc.contributor.authorCebi, Ahmet Taylan
dc.date.accessioned2024-09-29T16:06:33Z
dc.date.available2024-09-29T16:06:33Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to evaluate the effects of systemic and topical nonsteroidal anti-inflammatory agents on postoperative pain and edema and also gastrointestinal side effects after impacted third molar surgery. Materials and Methods: In this clinical study, 100 healthy patients with mandibular impacted third molar teeth in a similar position were included. After the operation, patients were divided into two groups, one group received Flurbiprofen tablets and the other group received Flurbiprofen 0.25% Oral spray. The pain was assessed postoperatively by Visual Analog Scale (VAS). The edema evaluation was measured on preoperative and postoperative 2nd and 7th days. Gastrointestinal adverse effects related to the use of nonsteroidal anti-inflammatory drug such as nausea, heartburn, dyspepsia, vomiting, and diarrhea were recorded according to information received from patients. Results: There was a statistically significant difference between the groups with regard to Visual Analog Scale levels at 6th, 8th, 12th, 24th, and 48th hours. 2nd-day edema measurements of the systemic nonsteroidal antiinflammatory drug group were found to be statistically lower than the local-topical nonsteroidal antiinflammatory drug group. Conclusion: Although the efficacy of topical nonsteroidal anti-inflammatory drugs on pain and edema is lower than systemic nonsteroidal anti-inflammatory drugs, it may be preferred because it has less gastrointestinal side effects.en_US
dc.identifier.doi10.17826/cumj.631371
dc.identifier.endpage147en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage141en_US
dc.identifier.trdizinid384463en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.631371
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/384463
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6908
dc.identifier.volume45en_US
dc.identifier.wosWOS:000522558800020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPainen_US
dc.subjectedemaen_US
dc.subjectthird molar teethen_US
dc.subjectflurbiprofenen_US
dc.subjectnonsteroidal anti-inflammatory agentsen_US
dc.titleEfficiency of topical and systemic flurbiprofen on pain and edema after impacted third molar surgery and comparison of gastrointestinal adverse effectsen_US
dc.typeArticleen_US

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