Association of Fragmented QRS with Subclinical Left Ventricular Dysfunction in Patients with Obstructive Sleep Apnea

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dc.authoridAcat, Murat/0000-0002-7163-4882
dc.authoridBulbul, Yilmaz/0000-0002-8488-3650
dc.authoridOnalan, Orhan/0000-0001-9780-7051
dc.contributor.authorAdar, Adem
dc.contributor.authorKiris, Abdulkadir
dc.contributor.authorBulbul, Yilmaz
dc.contributor.authorBektas, Huseyin
dc.contributor.authorAcat, Murat
dc.contributor.authorCasim, Hasan
dc.contributor.authorOnalan, Orhan
dc.date.accessioned2024-09-29T16:04:53Z
dc.date.available2024-09-29T16:04:53Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate whether fragmented QRS (fQRS) is associated with subclinical left ventricular (LV) dysfunction in patients with obstructive sleep apnea (OSA). Subjects and Methods: A total of 141 patients with OSA who had normal LV ejection fraction (LVEF) were included in the study. The fQRS was defined as the presence of an additional R wave, notching of R or S wave or the presence of fragmentation in 2 contiguous electrocardiography (ECG) leads. Subclinical LV dysfunction was defined as the presence of a tissue Doppler-derived Tei index of >= 0.5 in the absence of impaired LVEF (<50%) as assessed by transthoracic echocardiography. Results: Of the 141 patients, 71 (50.4%) had subclinical LV dysfunction. Overall, the prevalence of the fQRS was 61% (86/141). Patients with fQRS had significantly higher Tei indices than those without fQRS [median 0.66, interquartile range (IQR) 0.39 vs. median 0.40, IQR 0.15, p < 0.001]. The presence of fQRS on ECG predicted subclinical LV dys-function in univariate logistic regression analysis [odds ratio (OR) 6.69, 95% confidence interval (CI) 3.10-14.43]. The association remained significant after adjusting for all potential confounders (OR 4.59, 95% CI 1.94-10.87). Conclusion: fQRS on ECG was an independent predictor of subclinical LV dysfunction in patients with OSA. This simple tool might help to identify OSA patients who could be at risk for developing overt cardiac dysfunction. (C) 2015 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000382077
dc.identifier.endpage381en_US
dc.identifier.issn1011-7571
dc.identifier.issn1423-0151
dc.identifier.issue4en_US
dc.identifier.pmid26022145en_US
dc.identifier.startpage376en_US
dc.identifier.urihttps://doi.org/10.1159/000382077
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6386
dc.identifier.volume24en_US
dc.identifier.wosWOS:000356965800012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFragmented QRSen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectLeft ventricular dysfunctionen_US
dc.subjectMyocardial fibrosisen_US
dc.titleAssociation of Fragmented QRS with Subclinical Left Ventricular Dysfunction in Patients with Obstructive Sleep Apneaen_US
dc.typeArticleen_US

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