Can Juniperus communis L. oil improve nephropathy in diabetic rats

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dc.authoridKahraman, Tahir/0000-0003-4238-8528
dc.authoridYunusoglu, Oruc/0000-0003-1075-9574
dc.authoridBerkoz, Mehmet/0000-0003-4219-8054
dc.contributor.authorKahraman, Tahir
dc.contributor.authorBerkoz, Mehmet
dc.contributor.authorAllahverdiyev, Oruc
dc.contributor.authorMahmood, Evan Abdulkarim
dc.contributor.authorYildirim, Metin
dc.contributor.authorYalin, Serap
dc.date.accessioned2024-09-29T16:08:00Z
dc.date.available2024-09-29T16:08:00Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: Juniperus communis L. (J. communis) is a shrub belonging to family Cupressaceae L. mainly growth in Eurasia. The antioxidant and antidiabetic activity of aqueous extract of J. communis L. berries indicated benefits as a potent antidiabetic in streptozotocin induced diabetic albino rats. This study was carried out to determine whether J. communis L. oil supplement will effectively manage renal dysfunction in diabetic rats. Methods: Twenty eight rats were divided into 4 equal groups as follows; control group, diabetic group (45 mg/kg, i.p. streptozotocin), J. communis L. oil (200 mg/kg) treated group, and diabetic+J. communis L. oil (200 mg/kg) treated group. At the end of the experimental period, all rats were sacrificed and renal function parameters such as kidney antioxidant and lipid peroxidation markers and serum glucose, HbA1c, creatinine, serum urea, blood urea nitrogen (BUN), and serum total protein levels were measured in all groups. Results: HbA1c, serum glucose, urea, creatinine, BUN and, kidney lipid peroxidation levels increased (p<0.05), but serum total protein and antioxidant levels decreased in diabetic group comparing with control group (p<0.05). Furthermore, HbA1c, serum glucose, urea, creatinine and BUN and, kidney lipid peroxidation levels decreased and also, serum total protein and antioxidant levels increased in diabetic group treated with J. communis L. oil comparing with diabetic group (p<0.05). Conclusion: This study has provided that J. communis L. oil provide a protective effect on the kidney as evidenced by an improvement of the renal function tests as well as reduction in oxidative stress parameters in experimental diabetic nephropathy model.en_US
dc.identifier.doi10.33808/clinexphealthsci.543272
dc.identifier.endpage124en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage120en_US
dc.identifier.trdizinid375970en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.543272
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/375970
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7306
dc.identifier.volume10en_US
dc.identifier.wosWOS:000546311000007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectJuniperus communis L.en_US
dc.subjectdiabetesen_US
dc.subjectnephropathyen_US
dc.subjectantioxidanten_US
dc.subjectlipid peroxidationen_US
dc.subjectoxidative stressen_US
dc.titleCan Juniperus communis L. oil improve nephropathy in diabetic ratsen_US
dc.typeArticleen_US

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