Significance of C-reactive Protein in the Endoscopic Retrograd Cholangiopancreatography Related Pancreatitis

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dc.authoridAkin, Mete/0000-0003-2393-7990
dc.contributor.authorAkin, Mete
dc.contributor.authorKockar, Muhammed Cem
dc.contributor.authorAksakal, Gokhan
dc.contributor.authorSenol, Altug
dc.date.accessioned2024-09-29T16:09:35Z
dc.date.available2024-09-29T16:09:35Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: Endoscopic retrograde cholangiopancreatography ( ERCP) may be related with complications such as pancreatitis. C-reactive protein (CRP) can be provides reliable informations about post-ERCP complications and their severity. In our study, the role of CRP levels in the follow-up post-ERCP pancreatitis was investigated. Material and Method: 476 patients, whom performed ERCP for different indications, were retrospectively evaluated. 136 patients with measurement of serum amylase, lipase and CRP levels before and 1224 hours after the procedure were included the study. Alterations of these parameters in complicated and uncomplicated patiens were investigated. The role of CRP in the follow-up and prediction of severity of pancreatitis was investigated in 22 complicated patients with measurement of serum amylase, lypase and CRP levels 36-48 hours after the procedure. Pancreatitis were classified as mild, moderate, or severe. Results: Post-ERCP pancreatitis occured in 23 (17%) patients ( 9 mild and 14 moderate pancreatitis). The mean CRP levels (mg/l) at 12 to 24 hours were 23,5 +/- 24,18 in uncomplicated patients, and 59,2 +/- 44,87 in patiens with pancreatitis (p<0,05). The mean CRP levels (mg/l) at 12 to 24 hours were 30,8 +/- 14,24 in mild pancreatitis and 77,5 +/- 48,66 in moderate pancreatitis (p<0,05). The levels, respectively, at 36 to 48 hours were 37,7 +/- 20,73 and 84,6 +/- 48,31 (p<0,05). In the ROC curve analysis, significant cut-off values of CRP levels at 12 to 24 and 36 to 48 hours were 41 mg/l and 45 mg/l, respectively. Discussion: The follow-up of serum CRP levels after ERCP is a useful method for predicting and determining of severity of post-ERCP pancreatitis.en_US
dc.identifier.doi10.4328/JCAM.3567
dc.identifier.endpage466en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.startpage462en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.3567
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7649
dc.identifier.volume6en_US
dc.identifier.wosWOS:000215595200009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndoscopic Retrograde Cholangiopancreatographyen_US
dc.subjectPancreatitisen_US
dc.subjectC-Reactive Proteinen_US
dc.titleSignificance of C-reactive Protein in the Endoscopic Retrograd Cholangiopancreatography Related Pancreatitisen_US
dc.typeArticleen_US

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