The relationship of preoperative and postoperative serumcea and ca 19-9 levels with tumor localization, stage andoverall survival in patients with colorectal cancer

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dc.contributor.authorİnci, Fatih
dc.contributor.authorKarataş, Fatih
dc.date.accessioned2024-09-29T16:32:06Z
dc.date.available2024-09-29T16:32:06Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: To evaluate the prognostic value of pre/postoperative serum levels of Carcinoembryonic antigen (CEA), Carbohydrate antigen19-9 (CA 19-9), and their relationship with primary localization and stage of colorectal cancer (CRC) patients.Materials and Methods: 255 patients who underwent curative or palliative surgery with the diagnosis of CRC between 2015 and 2020were included in the study. The patients were divided into groups as right colon tumor and left colon tumor based on the region ofthe primary tumor. Baseline data on age, sex, location of primary tumor, disease stage, histological differentiation, BRAF and RASmutation situations and serum CEA and CA 19-9 levels were recorded before and after surgery. Individuals were followed for at leastsixty months or until they died. Overall survival (OS) and Disease Free Survival (DFS) rates were estimated using the Kaplan–Meiermethod. Results: 103 patients had right sided (41.4%) and 152 patients (59.6%) had left sided CRC. Most of the patients were in the early stage(71%). DFS and OS patients with left colon tumors were longer than the right. [(DFS, 32.18 (6-60) vs. 34.25 (6-60) months, p=0.332)and (OS, 41.16 (6-60) vs. 49.05 (11-60) months, p=0.002]. An assessment of the prognosis showed that the OS was significantlyworse in the patients with a high CEA level (p=0.001) and in the patients with a high CA 19-9 level (p=0.001). In multivariate analysis,normal serum CA 19-9 levels (p=0.002), RAS wild type tumor (p<0.001), early stage disease (p=0.004) were identified as a goodprognostic factors for OS of these patients. Conclusion: It was determined that left colon tumors had a longer life span than right side. Elevated levels of CEA and CA 19-9 preand postoperative in CRC have a worst prognosis than those with normal levels of these markers.en_US
dc.identifier.doi10.5455/annalsmedres.2020.09.979
dc.identifier.endpage732en_US
dc.identifier.issue4en_US
dc.identifier.startpage726en_US
dc.identifier.trdizinid464166en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.09.979
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/464166
dc.identifier.urihttps://hdl.handle.net/20.500.14619/11358
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe relationship of preoperative and postoperative serumcea and ca 19-9 levels with tumor localization, stage andoverall survival in patients with colorectal canceren_US
dc.typeArticleen_US

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