Evaluating the Role of Antibiotic Use in the Development of Cow's Milk Protein Allergy within the First Year of Life among the Patients Treated in the NICU
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mashhad Univ Med Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: It has been reported that the incidence of Cow's Milk Protein Allergy (CMPA) has increased in recent years, especially among infants in the first year of life. It is thought that the use of antibiotics may trigger the development of CMPA by causing intestinal dysbiosis and altering immune response, and thus, it may be a factor responsible for the supposed increase. The relationship between antibiotic use and the development of CMPA has been evaluated in very few studies in the literature. Thus, this study aimed to evaluate whether CMPA development is associated with antibiotic use during pregnancy or neonatal period. Method: During the study period, 1120 babies were followed up in our NICU, 975 of whom met the inclusion criteria. The development of CMPA within the first year of life was evaluated among the infants hospitalized and followed up in the Neonatal Intensive Care Unit (NICU) of Karabuk University, Faculty of Medicine, Training and Research Hospital, between January 1, 2017 and October 30, 2020. Results: The neonates whose mothers had used antibiotics received mechanical ventilation treatment at a significantly higher frequency (p = 0.042). There was no significant difference in the frequency of CMPA development between the infants of mothers with and without antibiotic use (p = 0.533). Compared to the babies who did not use antibiotics, the gestational week, birth weight, 1st and 5th minute APGAR scores of the babies who used antibiotics were significantly lower, and their frequency of mechanical ventilation treatment was significantly higher (p<0.001). There was no significant difference between infants who used and did not use antibiotics in terms of the frequency of CMPA development (p = 0.150). In general, it was found that the use of antenatal and postnatal antibiotics did not increase the development of CMPA. Conclusion: The data of our study contradicts the two study of which previously associated maternal and infant antibiotic use with the development of CMPA. This contradiction suggests that the aetiology of CMPA is multifactorial and more studies are needed to elucidate the antibiotic-CMPA relationship.
Açıklama
Anahtar Kelimeler
Antibiotic, Cow's milk protein allergy, Newborn
Kaynak
International Journal of Pediatrics-Mashhad
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
10
Sayı
2
