The prognostic effect of immunoscore in patients with clear cell renal cell carcinoma: preliminary results

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dc.authoridDEMIRCI, UMUT/0000-0002-4833-6721
dc.authoridBasar, Halil/0000-0003-1770-5165
dc.authoridBozdogan, Nazan/0000-0001-8484-5040
dc.authoridSELVI, ISMAIL/0000-0003-3578-0732
dc.contributor.authorSelvi, Ismail
dc.contributor.authorDemirci, Umut
dc.contributor.authorBozdogan, Nazan
dc.contributor.authorBasar, Halil
dc.date.accessioned2024-09-29T15:51:26Z
dc.date.available2024-09-29T15:51:26Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose This study aimed to evaluate the density of CD8(+) and CD3(+) tumor-infiltrating lymphocytes (TILs) and determine whether the immunoscore has any prognostic effect on the oncological outcomes in patients with clear cell renal cell carcinoma (RCC). Materials and methods A total of 129 patients diagnosed with clear cell RCC following radical or partial nephrectomy between 2009 and 2014 were retrospectively analyzed. Both tumor core (CT) and the invasive margin of nephrectomy specimens were assessed. The specimens were immunostained for anti-CD8(+) and anti-CD3(+) TILs. The patients were divided into three groups (favorable, intermediate, and poor risk) according to immunoscore levels. Results In the multivariate analysis, a favorable immunoscore (I3-4) was associated with prolonged disease-free survival (DFS), progression-free survival (PFS), and overall survival (OS) (HR 2.652, 2.848, and 2.933, respectively; all p < 0.001). The lower Fuhrman grade and pathological tumor-node-metastasis (TNM) stage had better DFS, PFS, and OS, whereas prolonged PFS was associated with a higher density of CD8(+) CT (HR 1.602, 95% CI 0.934-3.470; p = 0.014). The shorter DFS, PFS, and OS were observed in the group with poor immunoscore (I0-1) at the early TNM stage of RCC (p < 0.001). In the metastatic subgroup analysis, the immunoscore showed better estimation than the International Metastatic RCC Database Consortium model and the Memorial Sloan-Kettering Cancer Center risk model for progression and OS (p < 0.001). Conclusion The additional contributions of immunoscore to TNM stage, Fuhrman grade, and the WHO/ISUP 2016 grade for estimating oncological outcomes were found in ROC analysis. According to our preliminary results, immunoscore can be a promising prediction tool in clear cell RCC for postoperative oncological outcomes following nephrectomy.en_US
dc.description.sponsorshipDr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi (TR) [(the scientific research fund with the decision of dated 03.11.2017, numbered 1)] Funding Source: Medlineen_US
dc.identifier.doi10.1007/s11255-019-02285-0
dc.identifier.endpage34en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue1en_US
dc.identifier.pmid31541404en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-019-02285-0
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4068
dc.identifier.volume52en_US
dc.identifier.wosWOS:000512074300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD3(+)en_US
dc.subjectCD8(+)en_US
dc.subjectClear cell renal cell carcinomaen_US
dc.subjectImmunoscoreen_US
dc.subjectOncologic outcomesen_US
dc.subjectTumor-infiltrating lymphocytesen_US
dc.titleThe prognostic effect of immunoscore in patients with clear cell renal cell carcinoma: preliminary resultsen_US
dc.typeArticleen_US

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