Factors predicting hyperimmune response in COVID-19 patients presenting to the emergency department
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The aim of this study is to determine the predictive parameters that can be used in the early determination of hyperimmune response syndrome in the Emergency Department. Material and Methods: This is a cross-sectional, retrospective study. Patients over the age of 18 who were admitted to the emergency department with a pre-diagnosis of COVID-19, and who were admitted to the intensive care unit were included in the study. Demographic data and laboratory findings were obtained from the hospital information system and patient files. Patients' thoracic computerized tomography images were classified into two groups. The classic involvement includes bilateral basal ground-glass opacities, crazy paving, reverse halo, per lobular pattern, and peripheral consolidation. All other images were included as non-classic COVID-19 involvement. Results: A total of 202 patients were included. Hyperimmune response development was detected in 74 (36.6%) patients. When laboratory values were examined, ferritin and ALT values were found to be higher, WBC and lymphocyte values were found to be lower in patients who developed a hyperimmune response (p<0.01, p<0.01, p=0.038 and p=0.004, respectively). In the logistic regression analysis of the values that can be effective in the development of the hyperimmune response, classic imaging had a statistically significant effect (Odds ratio 0.449 [95% confidence interval, CI = 0.244-0.827], non-classic vs classic[reference]). No statistically significant effect was found in the analysis of other values. Discussion: Classical chest tomography findings can be useful as a preliminary parameter in the development of hyperimmune response.
Açıklama
Anahtar Kelimeler
COVID-19, Emergency, Cytokine, Ferritin, Lymphocyte
Kaynak
Annals of Clinical and Analytical Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
13
Sayı
4
