The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Obstructive Sleep Apnea syndrome (OSAS) is the most common condition among sleep-related respiratory disorders. The etiology is not clear. However, systemic and local inflammation in the respiratory tract of the patients has been acknowledged. Monocytes and macrophages play the critical role in the inflammation process. These cells participate in the release of the proinflammatory cytokines in inflammation sites. High-density lipoprotein (HDL) cholesterol is a molecule with an anti-inflammatory effect. Monocyte/HDL cholesterol ratio (MHR) is an inflammation marker being used recently. In our study, we aimed to compare inflammation marker levels between patients diagnosed with OSAS with subsequent polysomnography and the non-OSAS group, determine the relationship between the severity of OSAS and MHR and, investigate the utility of the MHR for diagnosing OSAS. Materials and Methods: The data from the patients' files who had polysomnography due to OSAS symptoms in our unit between July 2017 and December 2017 have been retrospectively analyzed, and polysomnography results were recorded. Demographic data and the results of biochemistry and complete blood count panels of patients with OSAS and who were not also were recorded. Results: Out of 147 patients who underwent polysomnography in the period identified, 104 were diagnosed with OSAS. Monocyte count and MHR values were significantly high (p<0.0001 in both) and HDL levels were significantly low (p=0.03) in OSAS group. There was also a moderately significant positive correlation between apnea-hypopnea index (AHI) and MHR (p<0.0001, r=0.411). Conclusion: MHR may be a useful tool for diagnosing OSAS. Because of the positive correlation between MHR and AHI which represents the severity of the disease, MHR may be used for the classification of OSAS.
Açıklama
Anahtar Kelimeler
Obstructive Sleep Apnea syndrome, monocyte, HDL, cholesterol, polysomnography
Kaynak
Meandros Medical and Dental Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
20
Sayı
3
