Clinical and Histopathological Features of Genitourinary Sarcomas: Our Experiences and Case Series at a Single Center

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dc.authoridSELVI, ISMAIL/0000-0003-3578-0732
dc.authoridGuven, Esref Oguz/0000-0003-4919-9383
dc.contributor.authorSelvi, Ismail
dc.contributor.authorGuven, Esref Oguz
dc.date.accessioned2024-09-29T16:08:33Z
dc.date.available2024-09-29T16:08:33Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The incidence of genitourinary sarcomas is very low, so the published reports in the literature are very limited. We aimed to present our experiences of eight cases originating from various genitourinary organs treated in our clinic. Materials and Methods: We retrospectively reviewed the data and postoperative follow-up findings of eight cases aged 3-72 years who were diagnosed as genitourinary sarcoma and treated between January 2013 and February 2017. Results: All eight cases were male and the mean age at diagnosis was 47.87 (range = 3-72) years. The most common site was paratesticular area (five cases, 62.5%) followed by kidney (two cases, 25%) and prostate (one case, 12.5%). Histological types of tumors were rhabdomyosarcoma (RMS) (two cases, 25%), liposarcoma (LPS) (two cases, 25%), leiomyosarcoma (LMS) (two cases, 25%), synovial sarcoma (one case, 12.5%) and malignant fibrous histiostoma (MFH) (one case, 12.5%). At a median follow-up of 23.5 (range = 4-62) months, the recurrence-free and progression-free survival rate was 50%, while the overall survival rate was 50%. Among the five paratesticular sarcomas, the worst prognosis was seen in LMS (local recurrence at the 4th, overall survival was 28 months) and MFH (local recurrence at the 8th, overall survival was 33 months). Among all sarcoma cases, LMS and synovial sarcoma were the histologic types with the worst prognosis. The histological types with the best prognosis were LPS and RMS with no recurrence or progression during follow-up. In all cases with a median tumor size of 52.5 mm (range = 11-210), LPS was found to have a better prognosis, although the largest tumor size was in renal LPS. According to FNCLCC classifications, local recurrence-free survival was significantly higher in grade II sarcomas than in grade III (p=0.042). Conclusion: Histopathological features and oncologic outcomes of genitourinary sarcomas differ. The prognosis of paratesticular sarcomas is better than other genitourinary organ sarcomas. LPS has higher cure rates after treatment in histological subtypes. The prognosis of histopathologically poorly differentiated subtypes and high-grade tumors is poor. If adjuvant treatments are not added, they may be fatal with local recurrence or distant metastasis in a short time.en_US
dc.identifier.doi10.4274/uob.galenos.2019.1193
dc.identifier.endpage98en_US
dc.identifier.issn2147-2270
dc.identifier.issue3en_US
dc.identifier.startpage93en_US
dc.identifier.trdizinid379187en_US
dc.identifier.urihttps://doi.org/10.4274/uob.galenos.2019.1193
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/379187
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7617
dc.identifier.volume18en_US
dc.identifier.wosWOS:000484342000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofUroonkoloji Bulteni-Bulletin of Urooncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFNCLCC grading systemen_US
dc.subjectoverall survivalen_US
dc.subjectgenitourinary sarcomasen_US
dc.subjectparatesticular sarcomasen_US
dc.titleClinical and Histopathological Features of Genitourinary Sarcomas: Our Experiences and Case Series at a Single Centeren_US
dc.typeArticleen_US

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