The Frequency of Atopic Dermatitis and Other Skin Manifestations in Infants with Cow's Milk Protein Allergy in Karabuk, Turkey

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dc.contributor.authorDogan, Erkan
dc.contributor.authorSevinc, Eylem
dc.contributor.authorGamsizkan, Zerrin
dc.contributor.authorKorkut, Burcu
dc.contributor.authorSevinc, Nergiz
dc.date.accessioned2024-09-29T16:06:42Z
dc.date.available2024-09-29T16:06:42Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground Atopic dermatitis (AD) is the most common skin disease in childhood, and Cow's milk protein allergy (CMPA) is the most common cause of food allergies in infancy and may be characterized by atopic dermatitis with skin involvement as the first finding. The aim of this study is to determine the serum eosinophil cationic protein (sECP) levels, eosinophil counts and the frequency of AD and other skin manifestation among infants with CMPA. Materials and Methods: This cross-sectional study was conducted in Karabuk province, Turkey. Eighty-three infants who were diagnosed with CMPA and followed at the Karabuk Training Hospital Pediatric outpatient clinic. The first group consisted of 52 infants presenting with skin manifestations. The second group consisted of 31 infants who were not presenting skin manifestations. The sECP level of infants in both groups was measured using an Immulite 2000 XPi analyzer Immunoassay System (Germany). Results: Of 83 infants with CMPA, 62.6% (n=52) were detected skin involvement as the first finding. The proportions of atopic dermatitis and urticaria in CMPA infants with skin involvement were 90.4% and 9.6% respectively. The median sECP level and eosinophil counts (56.5 ng/mL vs 470/mm(3), p-value=0.001), in skin manifestations with CMPA group were significantly higher than that in the CMPA group without skin manifestations (33.1 ng/mL vs. 270/mm(3), p-value=0.006). Conclusion This study revealed that AD is the most common skin manifestation of CMPA and also found higher sECP levels in infants with skin involvement. The frequency of both diseases, which are easily treated with elimination diet, is increasing day by day.en_US
dc.identifier.doi10.22038/IJP.2021.55765.4393
dc.identifier.endpage13184en_US
dc.identifier.issn2345-5047
dc.identifier.issn2345-5055
dc.identifier.issue3en_US
dc.identifier.startpage13177en_US
dc.identifier.urihttps://doi.org/10.22038/IJP.2021.55765.4393
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7001
dc.identifier.volume9en_US
dc.identifier.wosWOS:000632990500008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofInternational Journal of Pediatrics-Mashhaden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtopic dermatitisen_US
dc.subjectCow's milken_US
dc.subjectEosinophilen_US
dc.subjectInfanten_US
dc.subjectProtein allergyen_US
dc.subjectTurkeyen_US
dc.titleThe Frequency of Atopic Dermatitis and Other Skin Manifestations in Infants with Cow's Milk Protein Allergy in Karabuk, Turkeyen_US
dc.typeArticleen_US

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