The Value of Neutrophil-to-Lymphocyte Ratio and Epicardial Adipose Tissue Thickness in Heart Failure With Preserved Ejection Fraction

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dc.authoridColluoglu, Tugce/0000-0002-2227-6177
dc.contributor.authorColluoglu, Tugce
dc.contributor.authorAkin, Yesim
dc.date.accessioned2024-09-29T16:10:16Z
dc.date.available2024-09-29T16:10:16Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackgroundUsing epicardial adipose tissue thickness (EATt) and neutrophil-to-lymphocyte ratio (NLR) as individual indicators provides beneficial insight into the prognosis of patients suffering from heart failure with preserved ejection fraction (HFpEF).AimIn our study, we aimed to evaluate whether the combined evaluation of NLR and EATt would provide an advantage for identifying high-risk HFpEF patients according to hospitalization for heart failure (HHF) and left ventricular diastolic dysfunction (LVDD).MethodA total of 168 outpatients with HFpEF were retrospectively analyzed. The predictive performance of two inflammatory variables was assessed by the receiver operating characteristic curve and a one-way analysis of variance (ANOVA) test. The patients were stratified into three distinct risk categories based on the established cut-off values for EATt and NLR as follows: Group I, high risk; Group II, middle risk; and Group III, low risk.ResultsPatients in Group I had the highest risk for HHF and the presence of LVDD (p=0.001 for HHF, p=0.011 for LVDD). Patients in Group I also exhibited more symptomatic and a greater number of comorbidities. In Group I, more structural remodeling (enlarged left ventricular end-systolic volume index (LVESVI) and left atrial volume index (LAVI)) and associated signs of increased intracardiac pressure (elevated E/A ratio, medial E/e') were observed.ConclusionThe results of our study indicate that the use of both EATt and NLR among patients with HFpEF may provide better accuracy in predicting HHF and LVDD compared to the use of either EATt or NLR alone.en_US
dc.identifier.doi10.7759/cureus.42846
dc.identifier.issn2168-8184
dc.identifier.issue8en_US
dc.identifier.pmid37538972en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.42846
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8084
dc.identifier.volume15en_US
dc.identifier.wosWOS:001047624400018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectheart failure with preserved ejection fraction (hfpef)en_US
dc.subjectleft ventricular functionen_US
dc.subjecthospitalisation for heart failureen_US
dc.subjectneutrophil-to-lymphocyte ratioen_US
dc.subjectepicardial adipose tissue thicknessen_US
dc.titleThe Value of Neutrophil-to-Lymphocyte Ratio and Epicardial Adipose Tissue Thickness in Heart Failure With Preserved Ejection Fractionen_US
dc.typeArticleen_US

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