Biofilms in chronic rhinosinusitis with polyps: is eradication possible?

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dc.authoridCelik, Hakan Hamdi/0000-0002-7909-7604
dc.contributor.authorKorkmaz, Hakan
dc.contributor.authorOcal, Bulent
dc.contributor.authorTatar, Emel Cadalli
dc.contributor.authorTatar, Ilkan
dc.contributor.authorOzdek, Ali
dc.contributor.authorSaylam, Guleser
dc.contributor.authorCelik, Hakan Hamdi
dc.date.accessioned2024-09-29T15:51:03Z
dc.date.available2024-09-29T15:51:03Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe objective of the study was to reveal if mometasone furoate nasal spray as monotherapy or combined with long-term oral clarithromycin have influence on biofilms in chronic rhinosinusitis with polyps. The study is a randomized controlled trial in a tertiary referral hospital. Thirty-four patients with chronic rhinosinusitis completed the study. In the first group, 19 patients received mometasone furoate nasal spray 200 mu g once daily for 8 weeks. In the second group, 15 patients received oral clarithromycin 500 mg twice daily for 2 weeks and continued once daily 250 mg tablet for subsequent 6 weeks, plus mometasone furoate. Scanning electron microscopy was the primary outcome measure. Secondary outcome measures included computerized tomography and sinonasal outcome test-20 items. Mucosal biofilms were detected in 23 of 34 (68 %) patients on pretreatment polyp samples. After the treatment, biofilms disappeared in 1 of 11 patients in the first group, whereas the eradication of biofilms was evident in 6 of 12 (50 %) patients in the second group. Tomography scores improved in eight patients of each group (42.1 and 53.4 %, respectively). The comparison of improvements did not reveal significant difference between the groups. The overall symptom scores improved compared to the baseline levels. The mean changes of -8.8421 and -11.4000 in the first and second group, respectively, were not statistically different. Adding long-term low-dose oral macrolides to nasal steroids was effective in the eradication of biofilm. However, we were not able to demonstrate that combined therapy was superior in terms of the improvement in tomography and symptom scores.en_US
dc.identifier.doi10.1007/s00405-013-2756-x
dc.identifier.endpage2702en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue10en_US
dc.identifier.pmid24510176en_US
dc.identifier.startpage2695en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-013-2756-x
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3870
dc.identifier.volume271en_US
dc.identifier.wosWOS:000341498500014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasal polypsen_US
dc.subjectBiofilmen_US
dc.subjectScanning electron microscopyen_US
dc.subjectClarithromycinen_US
dc.subjectNasal steroiden_US
dc.titleBiofilms in chronic rhinosinusitis with polyps: is eradication possible?en_US
dc.typeArticleen_US

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