IS TESTICULAR MICROLITHIASIS A REALLY INNOCENT CONDITION? ITS EFFECTS ON ONCOLOGICAL OUTCOMES OF GERM CELL TESTICULAR CANCER: AN OBSERVATIONAL STUDY

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dc.authoridSarikaya, Selcuk/0000-0001-6426-1398
dc.contributor.authorSelvi, Ismail
dc.contributor.authorSarikaya, Selcuk
dc.contributor.authorBasar, Halil
dc.date.accessioned2024-09-29T16:12:17Z
dc.date.available2024-09-29T16:12:17Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOBJECTIVES: Although it is a well known condition that presence of testicular microlithiasis (TM) with the co-occurrence of specific risk factors such as history of previous germ cell testicular cancer (GCTC), infertility, undescended testes or atrophic testes have high risks for GCTC development,TM is still a controversial topic. Its effects on oncological outcomes have still not been investigated in detail. In this study, we aimed to evaluate whether the presence of TM has an effect on GCTC prognosis and oncological outcomes. METHODS: Seventy five patients among 93 patients who underwent radical orchidectomy between January 2010 and February 2016 were selected and divided into two groups. Group I consisted of 51 patients without TM. Group II consisted of 24 patients with TM. Each groups were compared in terms of demographic datas, prognostic risk factors, complete blood count parameters and oncological outcomes. RESULTS: During the median follow-up of 58 (1-106) months, a significantly higher local recurrence rate (54.2% vs. 3.9%, p<0.001), distant metastasis rate (58.3% vs. 5.9%, p<0.001) and lower cancer-spesific survival rate (45.8% vs. 94.1%, p<0.001) were observed in patients with TM. In this group, the duration of recurrence-free survival (47.65 +/- 9.45 vs.101.96 +/- 2 .80 months, p<0.001), metastasis-free survival (49.50 +/- 8.88 vs. 100.00 +/- 3.36 months, p<0.001) and cancer-specific survival (54.37 +/- 8.76 vs. 100.19 +/- 3.25 months, p<0.001) were also statistically lower. In multivariate analysis, beta-hCG, LDH, neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio and the presence of undescended testis were found as independent predictive factors for local recurrence, distant metastasis and cancer-specific survival. Red blood cell distribution width and the presence of testicular microlithiasis were found to be independent predictive factors for local recurrence. CONCLUSION: According to our results, bilateral TM was associated with higher rates of local recurrence, distant metastasis and cancer spesific mortality in presence of risk factors, regardless of classic or limited microlithiasis.en_US
dc.identifier.endpage225en_US
dc.identifier.issn0004-0614
dc.identifier.issn1576-8260
dc.identifier.issue3en_US
dc.identifier.pmid32240112en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8643
dc.identifier.volume73en_US
dc.identifier.wosWOS:000541654900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIniestares, S.A.en_US
dc.relation.ispartofArchivos Espanoles De Urologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGerm cell testicular canceren_US
dc.subjectMonocyte/lymphocyte ratioen_US
dc.subjectNeutrophil/lymphocyte ratioen_US
dc.subjectOncological outcomesen_US
dc.subjectRed blood cell distribution widthen_US
dc.subjectTesticular microlithiasisen_US
dc.titleIS TESTICULAR MICROLITHIASIS A REALLY INNOCENT CONDITION? ITS EFFECTS ON ONCOLOGICAL OUTCOMES OF GERM CELL TESTICULAR CANCER: AN OBSERVATIONAL STUDYen_US
dc.typeArticleen_US

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