The protective effects of pentoxifylline on contrast induced nephropathy in rats
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Tarih
2019
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Pentoxifylline (PTX), which has antioxidant and immunomodulatory effects, has beenshown to attenuate renal ischemia-reperfusion injury. We aimed to investigate whether PTX mighthave a preventive role against the development of contrast induced nephropathy (CIN).Material and Methods: A total of 24 Wistar-albino female rats were randomly divided into fourgroups (n=6 each) as follows; control (C), contrast material (CM), PTX, and PTX+CM. Except thecontrol and CM groups, the groups were given PTX once daily orally for 5 days. CIN was inducedby administration of intravenous high-osmole contrast material-diatrizoate (6 mL/kg) after 48 hourof dehydration. Basal and post-CIN kidney function parameters, inflammatory parameters, serumand renal tissue oxidative stress markers (serum levels of advanced oxidation protein product andmalondialdehyde), and histopathological lesions were assessed.Results: The increase in serum creatinine and blood urea nitrogen levels was significantly higheronly in the CM group (P<0.05). Absolute changes of serum creatinine levels in the PTX, PTX+CMand C groups were significantly lower than those observed in the CM group (P<0.05). There wasno significant decrease in creatinine clearance in any group except CM. The differences among thegroups regarding the absolute change in creatinine clearance were not significant. Serum levels ofadvanced oxidation protein product and malondialdehyde were significantly lower in PTX+CM thanthose in CM (P<0.05). Histopathological lesions in the CM group were more advanced (P<0.05).Conclusion: In conclusion, the study suggests that PTX may prevent CIN.
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Genel ve Dahili Tıp
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5
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3
