Effects of the genetic variants and serum levels of TIMP-1 and TIMP-2 on type 2 diabetes mellitus in the Turkish population

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dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridCelik, Dr. Faruk/0000-0003-2433-0277
dc.contributor.authorCelik, Faruk
dc.contributor.authorYilmaz, Umit
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorOzyavuz, Kerem
dc.contributor.authorBasaran, Cem
dc.contributor.authorFazliogullari, Osman
dc.contributor.authorErgen, Arzu
dc.date.accessioned2024-09-29T16:09:35Z
dc.date.available2024-09-29T16:09:35Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: Genetic and environmental factors are very important in the formation of type 2 diabetes mellitus (T2DM). Tissue inhibitors of matrix metalloproteinases (TIMPs) play central roles in inhibition of the extent of extracellular matrix degradation. The aim of this study is to investigate serum levels and gene polymorphisms of TIMP-1 and TIMP-2, and their effects on T2DM in the Turkish population. Material and Methods: One hundred seventeen patients with T2DM and 127 healthy controls were included in this study. TIMP-1 372 T>C, TIMP-2 303C>T, and TIMP-2 418 G>C polymorphisms were determined by PCR-RFLP method and serum TIMPs levels were measured by ELISA. Results: The frequencies of the TT genotype and T allele of the TIMP-2 303 C>T polymorphism were significantly higher in the patient group than in the control group. The frequency of the C allele for TIMP-2 418 G>C polymorphism was significantly higher in the control group than in patients. TIMP-1 372 T>C polymorphism was not statistically significant between patients and controls. Additionally, TIMP-1 serum levels were statistically higher in T2DM patients than in controls. Discussion: This study provides the first evidence that the TT genotype and T allele of the TIMP-2 303 C>T polymorphism significantly contribute to the risk of T2DM in the Turkish population. Also, carrying the C allele of the TIMP-2 418 G>C polymorphism had a protective effect against the development of T2DM. In addition, our results suggest that the C allele of the TIMP-1 372 T>C polymorphism may have protective effects against the development of T2DM.en_US
dc.description.sponsorshipResearch Support Unit of Istanbul University [9865]en_US
dc.description.sponsorshipFunding: This study was supported by the Research Support Unit of Istanbul University, project no: 9865.en_US
dc.identifier.doi10.4328/ACAM.21788
dc.identifier.endpage98en_US
dc.identifier.issn2667-663X
dc.identifier.issue2en_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.21788
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7641
dc.identifier.volume15en_US
dc.identifier.wosWOS:001157822900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectType 2 Diabetes Mellitus (T2DM)en_US
dc.subjectPolymorphismen_US
dc.subjectTIMP-1en_US
dc.subjectTIMP-2en_US
dc.subjectELISAen_US
dc.titleEffects of the genetic variants and serum levels of TIMP-1 and TIMP-2 on type 2 diabetes mellitus in the Turkish populationen_US
dc.typeArticleen_US

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