Subcapsular orchiectomy versus total orchiectomy and LHRH analogue in the treatment of hormone-sensitive metastatic prostate cancer: a different perspective in evaluation of the psychosocial effects

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dc.authoridBasar, Halil/0000-0003-1770-5165
dc.authoridSELVI, ISMAIL/0000-0003-3578-0732
dc.contributor.authorSelvi, Ismail
dc.contributor.authorBasar, Halil
dc.date.accessioned2024-09-29T15:51:05Z
dc.date.available2024-09-29T15:51:05Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose We aimed to compare total orchiectomy, subcapsular orchiectomy, and luteinizing hormone-releasing hormone (LHRH) analogue treatment in patients with hormone-sensitive metastatic prostate cancer in terms of efficacy of androgen deprivation treatment (ADT), patient satisfaction, health-related quality of life (HRQoL), development of phantom testis syndrome (PTS), and post-traumatic stress disorder (PTSD). Method Among 272 patients treated between July 2015 and January 2019, 189 patients were enrolled in this prospective, cohort study and the patients were divided into three groups: group I, bilateral total orchiectomy (n66); group II, bilateral subcapsular orchiectomy (n63); and group III, LHRH analogue treatment (n60). The adequacy of ADT was routinely monitored every 3 months and clinical parameters were evaluated. After 6 to 36 months following ADT, questionnaires were used to evaluate PTS, PTSD, and HRQoL during outpatient visits. The patient satisfaction was questioned as yes/no. Results Adequate castration was provided with all three treatments, while the presence and frequency of PTS and severity of PTSD were lower, and patient satisfaction related to ADT and all components of HRQoL were better in patients undergoing subcapsular orchiectomy than those undergoing total orchiectomy. All findings except for PTS were similar in patients undergoing subcapsular orchiectomy and LHRH analogue treatment. In analysis of all patients, total incidence of PTS was 43.4% and PTSD was reported to be 48.7%. A strong relationship was found between PTSD and phantom testis pain (r0.621,p < 0.001). Conclusions Subcapsular orchiectomy has less psychosocial side effects than total orchiectomy and is similar to LHRH analogue treatment. It can be a reliable, cheaper, and fast-acting alternative to LHRH analogue treatment.en_US
dc.identifier.doi10.1007/s00520-019-05266-2
dc.identifier.endpage4326en_US
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue9en_US
dc.identifier.pmid31912363en_US
dc.identifier.startpage4313en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-019-05266-2
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3882
dc.identifier.volume28en_US
dc.identifier.wosWOS:000551527900043en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care in Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHealth-related quality of lifeen_US
dc.subjectHormone-sensitive metastatic prostate canceren_US
dc.subjectPhantom testis syndromeen_US
dc.subjectPost-traumatic stress disorderen_US
dc.subjectSubcapsular orchiectomyen_US
dc.titleSubcapsular orchiectomy versus total orchiectomy and LHRH analogue in the treatment of hormone-sensitive metastatic prostate cancer: a different perspective in evaluation of the psychosocial effectsen_US
dc.typeArticleen_US

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