Impact of The Ion Channel Blockage on the Collective Spiking Regularity of a Scale-Free Neuronal Network

Basit Öğe Kaydı
dc.contributor.authorYilmaz, Ergin
dc.contributor.authorOzer, Mahmut
dc.contributor.authorCavusoglu, Abdullah
dc.date.accessioned2024-09-29T16:00:37Z
dc.date.available2024-09-29T16:00:37Z
dc.date.issued2012
dc.departmentKarabük Üniversitesien_US
dc.description1st World Conference on Innovation and Software Development (INSODE) -- OCT 02-10, 2011 -- Bahcesehir Univ, Istanbul, TURKEYen_US
dc.description.abstractThe voltage-gated ion channels embedded in biological membranes play crucial roles on the generation and transmission of action potentials. Therefore, understanding of impacts of each ion channel is of great importance for the dynamics of neuronal networks. Among the others, one method on this way is to block a specific ion channel type while keeping the remaining ion channel types active across the membrane and to observe their impact on neuronal dynamics. In this study, we study the effects of sodium and potassium channels blockage on the collective spiking regularity of a scale-free neuronal network with stochastic Hodgkin-Huxley neurons, and investigate how the dependence of the collective spiking regularity on the membrane area or cell size varies with the coupling constant between neurons. Results reveal that the collective spiking regularity exhibits coherence resonance (CR) depending on the channel blockage scaling factor and the cell size, where potassium channel blockage enhances the collective spiking regularity whereas sodium channel blockage decreases it. We show that there is a lower limit for the coupling constant which warrants the CR behavior. We also show that the maximal regularity is obtained for a smaller cell size with the increasing the value of the coupling constant.en_US
dc.identifier.doi10.1016/j.protcy.2012.02.037
dc.identifier.endpage204en_US
dc.identifier.issn2212-0173
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1016/j.protcy.2012.02.037
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5239
dc.identifier.volume1en_US
dc.identifier.wosWOS:000318909900035en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofFirst World Conference On Innovation and Computer Sciences (Insode 2011)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIon Channel Noiseen_US
dc.subjectCoherence Resonanceen_US
dc.subjectNeuronen_US
dc.subjectScale-Free Networken_US
dc.titleImpact of The Ion Channel Blockage on the Collective Spiking Regularity of a Scale-Free Neuronal Networken_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu