Genes Associated With Alcohol Outcomes Show Enrichment of Effects With Broad Externalizing and Impulsivity Phenotypes in an Independent Sample

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dc.authoridEdenberg, Howard/0000-0003-0344-9690
dc.authoridRangaswamy, Madhavi/0000-0002-6140-889X
dc.authoridBucholz, Kathleen/0000-0003-3794-0736
dc.authoridTischfield, Jay/0000-0003-3217-8287
dc.authoridKuperman, Samuel/0000-0002-5995-1981
dc.contributor.authorAliev, Fazil
dc.contributor.authorWetherill, Leah
dc.contributor.authorBierut, Laura
dc.contributor.authorBucholz, Kathleen K.
dc.contributor.authorEdenberg, Howard
dc.contributor.authorForoud, Tatiana
dc.contributor.authorDick, Danielle M.
dc.date.accessioned2024-09-29T16:11:28Z
dc.date.available2024-09-29T16:11:28Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N=2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman's Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability. Method: We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes. Results: For all phenotypes, there was significant enrichment of association results (p<.05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p<.05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes. Conclusions: We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we fmd significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems.en_US
dc.description.sponsorshipNational Institutes of Health (NIH) [U10AA008401]; NIH [K02AA018755]en_US
dc.description.sponsorshipThis national collaborative study is supported by National Institutes of Health (NIH) Grant U10AA008401. This work was also funded by NIH Grant K02AA018755 (to Danielle M. Dick).en_US
dc.identifier.endpage46en_US
dc.identifier.issn1937-1888
dc.identifier.issn1938-4114
dc.identifier.issue1en_US
dc.identifier.pmid25486392en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8462
dc.identifier.volume76en_US
dc.identifier.wosWOS:000348625300004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAlcohol Res Documentation Inc Cent Alcohol Stud Rutgers Univen_US
dc.relation.ispartofJournal of Studies On Alcohol and Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenome-Wide Associationen_US
dc.subjectDependenceen_US
dc.subjectLinkageen_US
dc.subjectRisken_US
dc.subjectGeneticsen_US
dc.subjectGabra2en_US
dc.subjectPersonalityen_US
dc.subjectDisordersen_US
dc.subjectVariantsen_US
dc.subjectValidityen_US
dc.titleGenes Associated With Alcohol Outcomes Show Enrichment of Effects With Broad Externalizing and Impulsivity Phenotypes in an Independent Sampleen_US
dc.typeArticleen_US

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