Comparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102

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dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.contributor.authorHacioglu, Muhammet Bekir
dc.contributor.authorKostek, Osman
dc.contributor.authorKurt, Nazmi
dc.contributor.authorKucukarda, Ahmet
dc.contributor.authorGokyer, Ali
dc.contributor.authorUstabasioglu, Fethi Emre
dc.contributor.authorKaratas, Fatih
dc.date.accessioned2024-09-29T16:12:17Z
dc.date.available2024-09-29T16:12:17Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: To assess whether regorafenib and TAS-102 treatments are associated with a change in Skeletal Muscle Area (SMA) as well as to compare Skeletal Muscle Mass (SMM) loss levels between regorafenib and TAS-102 treatments and prognostic significance in the patients with metastatic colorectal cancer (mCRC). Methods: A total of 36 mCRC patients, who received regorafenib or TAS-102 in the third-line and subsequent settings were assessed in the analysis. SMM changes were assessed with CT scans findings, and they were categorized into two groups as SMM-loss (SMM decrease >= 2%) and SMM-stable (SMM change <2%). Results: The SMM change after regorafenib therapy was significantly worse compared with TAS-102 therapy (p=0.001). The median overall survival (OS) was longer in SMM-stable group than in SMM-loss group (12.8 months; 95%CI:9.8-15.7) vs. 6.4 months; 95%CI:5.2-7.7, respectively;p=0.04). Cox regression analysis showed that SMM loss was independent prognostic indicator for OS (HR, 2.87; 95%CI: 1.07-7.42, p=0.03). Conclusion: Although patients who received regorafenib had more SMM loss than those who received TAS-102, there was no difference in OS between drugs.en_US
dc.identifier.endpage2204en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue5en_US
dc.identifier.pmid31786894en_US
dc.identifier.startpage2198en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8660
dc.identifier.volume24en_US
dc.identifier.wosWOS:000501762000062en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmetastatic colorectal canceren_US
dc.subjectregorafeniben_US
dc.subjectTAS-102en_US
dc.subjectsarcopeniaen_US
dc.subjectskeletal muscle massen_US
dc.titleComparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102en_US
dc.typeArticleen_US

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