The evaluation of inflammatory process, endothelial dysfunction and oxidative stress in sleep apnea

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dc.contributor.authorDundar, Yusuf
dc.contributor.authorTatar, Emel Cadalli
dc.contributor.authorSaylam, Guleser
dc.contributor.authorKorkmaz, Hakan
dc.contributor.authorSelcuk, Omer Tarik
dc.contributor.authorOzdek, Ali
dc.contributor.authorArdic, Sadik
dc.date.accessioned2024-09-29T16:06:54Z
dc.date.available2024-09-29T16:06:54Z
dc.date.issued2014
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: To investigate the correlation of inflammatory process, endothelial dysfunction and oxidative stress with obstructive sleep apnea (OSA). Methods: In our prospective cross-sectional clinical study in a tertiary referral hospital, we evaluated 63 patients with newly diagnosed OSA and 9 simple snorers. Each patient was evaluated in terms of additional systemic diseases and laboratory tests. In addition to routine blood analysis; oxidative stress markers (leptine, RBP), vascular endothelial markers (ICAM-I, VCAM-I) and inflammatory markers (Crp, IL-6, TNF-alpha, isoprostane) were analyzed. Polysomnography test was performed and study population was divided into four groups depending on their AHI values. The levels of markers were analyzed and compared between the four groups. Results: There was a weak correlation between the isoprostane levels and mean apnea duration and also a mild correlation to the maximum apnea duration. A weak correlation was detected between leptine and VCAM levels to age and also a weak negative correlation was detected between CRP levels to age. The leptin levels were found to be mildly correlated to BMI and abdominal circumference. The ICAM levels were found to have a weak correlation to BMI and abdominal circumference. Conclusion: Our results indicate a correlation between sleep apnea and oxidative stress. These results may help to explain the association of comorbid diseases with OSAS. Further investigators should aim to explain key steps of inflammatory response in sleep apnea.en_US
dc.identifier.doi10.2399/jmu.2014002007
dc.identifier.endpage65en_US
dc.identifier.issn2149-7109
dc.identifier.issn2149-6498
dc.identifier.issue2en_US
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.2399/jmu.2014002007
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7121
dc.identifier.volume4en_US
dc.identifier.wosWOS:000219465800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDeomed Publ, Istanbulen_US
dc.relation.ispartofEnt Updatesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSleep apneaen_US
dc.subjectinflammationen_US
dc.subjectoxidative stressen_US
dc.subjectvascular endotheliaen_US
dc.titleThe evaluation of inflammatory process, endothelial dysfunction and oxidative stress in sleep apneaen_US
dc.typeArticleen_US

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