Impact of triglyceride-glucose index on intracoronary thrombus burden in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

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dc.authoridKokturk, Ugur/0000-0003-0459-9295
dc.authoridOnalan, Orhan/0000-0001-9780-7051
dc.contributor.authorKokturk, Ugur
dc.contributor.authorOnalan, Orhan
dc.contributor.authorSomuncu, Mustafa Umut
dc.contributor.authorAkgul, Ozgur
dc.contributor.authorUygur, Begum
dc.contributor.authorPusuroglu, Hamdi
dc.date.accessioned2024-09-29T16:00:29Z
dc.date.available2024-09-29T16:00:29Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground and aims: We aimed to investigate the relationship between triglyceride glucose (TyG) index and intracoronary thrombus burden in patients with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Methods and results: A total of 468 consecutive patients who were admitted with STEMI and underwent primary PCI were included in the study. TyG index was calculated as ln [fasting triglycerides (mg/dL) x fasting plasma glucose (mg/dL)/2]. According to the angiographic reclassified thrombolysis in myocardial infarction (TIMI) thrombus grade, patients were divided into two groups as small thrombus burden (STB) with TIMI thrombus grade 0-3, and large thrombus burden (LTB) with TIMI thrombus grade 4-5. TyG index was significantly higher in the LTB group than in the STB group (9.11 +/- 0.86 vs 8.89 +/- 0.62; p = 0.002). In multivariate analysis, TyG index was found to be an independent predictor of LTB in STEMI patients who underwent primary PCI [OR (95 % CI): 1.470 (1.090-1.982), p = 0.012]. The area under the curve (AUC) of TyG index predicting LTB was 0.568 (95 % CI 0.506-0.631; p = 0.023), with the best cut-off value of 8.87. In the classification according to TyG index cut-off value, the frequency of LTB was found to be significantly higher in the high TyG index group than in the low TyG index group (33.6 % vs 21.2 %; p = 0.003). Conclusion: TyG index, a valid surrogate marker of insulin resistance, is an independent predictor of LTB in STEMI patients who underwent primary PCI and can be used as an indicator of increased intracoronary thrombus burden. (c) 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.numecd.2023.12.025
dc.identifier.endpage867en_US
dc.identifier.issn0939-4753
dc.identifier.issn1590-3729
dc.identifier.issue4en_US
dc.identifier.pmid38336545en_US
dc.identifier.startpage860en_US
dc.identifier.urihttps://doi.org/10.1016/j.numecd.2023.12.025
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5180
dc.identifier.volume34en_US
dc.identifier.wosWOS:001224009900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofNutrition Metabolism and Cardiovascular Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectST-elevation myocardial infarctionen_US
dc.subjectTyG indexen_US
dc.subjectthrombus burdenen_US
dc.subjectHOMA-IRen_US
dc.titleImpact of triglyceride-glucose index on intracoronary thrombus burden in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary interventionen_US
dc.typeArticleen_US

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