Comparison of Risk Factors and Outcomes in Carbapenem-Resistant and Carbapenem-Susceptible Gram-Negative Bacteremia

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dc.authoridYildiz Sevgi, Dilek/0000-0002-6047-4879
dc.authoridCetin, Sinan/0000-0002-0673-9354
dc.contributor.authorCetin, Sinan
dc.contributor.authorDokmetas, Ilyas
dc.contributor.authorHamidi, Aziz Ahmad
dc.contributor.authorBayraktar, Banu
dc.contributor.authorGunduz, Alper
dc.contributor.authorSevgi, Dilek Yildiz
dc.date.accessioned2024-09-29T16:06:09Z
dc.date.available2024-09-29T16:06:09Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Carbapenem-resistant Gram-negative bacteremia (CR-GNB) is seen with increasing frequency and result in high mortality. The aim of this study was to compare the risk factors and results of carbapenem-resistant and carbapenem-susceptible Gram-negative bacteremia and to determine the factors related to mortality. Methods: The study was conducted as a retrospective observational comparative case series between June 2016 and November 2017 in Sisli Hamidiye Etfal Training and Research Hospital. The patients were divided into two groups as carbapenem-susceptible and carbapenem-resistant according to antibiotic susceptibility data of blood cultures. The risk factors for the development of carbapenem resistance, length of hospital stay, mortality rates, and mortality related factors were investigated between these two groups. Results: Two hundred and eleven cases were included in the study. Of these cases, 54 were resistant to carbapenem and 157 were susceptible to carbapenem. Mortality occurred in 60 (28.4%) patients. The 14 and 28 day mortality rates of patients with carbapenem resistance were significantly higher than those without carbapenem resistance. There was no statistically significant difference between two groups in length of stay in the hospital after bacteremia. Pittsburgh bacteremia score, cardiovascular disease, urinary catheterization, and inappropriate empirical antibiotic therapy were the most significant risk factors for mortality. Conclusions: Carbapenem resistance is associated with increased mortality and inappropriate empirical antibiotic treatment increases mortality. Therefore, patients should be evaluated for risk factors in predicting CR-GNB and treatment for resistant pathogens should be applied in appropriate patients.en_US
dc.identifier.doi10.14744/SEMB.2020.49002
dc.identifier.endpage404en_US
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue3en_US
dc.identifier.pmid34712083en_US
dc.identifier.startpage398en_US
dc.identifier.trdizinid485644en_US
dc.identifier.urihttps://doi.org/10.14744/SEMB.2020.49002
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/485644
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6666
dc.identifier.volume55en_US
dc.identifier.wosWOS:000702751500017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofMedical Bulletin of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacteremiaen_US
dc.subjectcarbapenem-resistanten_US
dc.subjectgram-negativeen_US
dc.subjectmortality: risk factorsen_US
dc.titleComparison of Risk Factors and Outcomes in Carbapenem-Resistant and Carbapenem-Susceptible Gram-Negative Bacteremiaen_US
dc.typeArticleen_US

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