Protection of lutein against the neurotoxicity of cisplatin in the rat brain

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dc.authoridhttps://orcid.org/0000-0001-8410-2685
dc.authoridhttps://orcid.org/0000-0002-0956-8204
dc.authoridhttps://orcid.org/0000-0002-6093-3588
dc.contributor.authorBilgiç, Sedat
dc.contributor.authorAktaş, İbrahim
dc.contributor.authorYahyazadeh, Ahmad
dc.date.accessioned2024-12-30T09:14:45Z
dc.date.available2024-12-30T09:14:45Z
dc.date.issued2024-12-01
dc.departmentFakülteler, Tıp Fakültesi, Acil Tıp Bilimleri Bölümü
dc.description.abstractOne of the biggest problems of cancer treatment is the harmful effects of these drugs on the healthy tissues and organs of the organism. Our study aims to determine the possible protective effects of Lutein (L) against the toxicity of the pharmacological substance Cisplatin (CS), which is used in the treatment of cancer, in the brain of rats, through biochemical and histopathological tests. In our study, lutein (L) (100 mg/kg, orally) was administered for brain toxicity caused by CS (10 mg/kg, intraperitoneal (i.p.)). The study was completed in 7 days with a total of 28 rats from 4 groups, each consisting of 7 subjects. Control, L, CS and CS + L. A decrease in MDA level and an increase in CAT, GSH and SOD levels were observed in the CS + L group compared to the CS group. In histopathological examinations, no significant pathological changes were detected in the cerebrum, while degeneration in Purkinje cells and apoptosis in neurons in the molecular and granular layers in the cerebellum were detected. It is understood from the study that L alleviates the results of oxidative stress, increases antioxidant functions and positively supports brain functions. It also demonstrates the ability of L to prevent CS-induced brain damage. Ultimately, L appears to be a applicable pharmacological agent in this damage.
dc.identifier10.1016/j.tice.2024.102609
dc.identifier.citationBilgiç, S., Aktaş, İ., & Yahyazadeh, A. (2024). Protection of lutein against the neurotoxicity of cisplatin in the rat brain. Tissue & cell, 91, 102609. https://doi.org/10.1016/j.tice.2024.102609
dc.identifier.doi10.1016/j.tice.2024.102609
dc.identifier.issn0040-8166
dc.identifier.pmid39561514
dc.identifier.scopus2-s2.0-85209231434
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1016/j.tice.2024.102609
dc.identifier.urihttps://hdl.handle.net/20.500.14619/14936
dc.identifier.volume91
dc.identifier.wosWOS:001360644600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTissue and Cell
dc.relation.ispartofseriesTissue and Cell
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidant
dc.subjectBrain
dc.subjectCisplatin
dc.subjectLutein
dc.subjectRat
dc.titleProtection of lutein against the neurotoxicity of cisplatin in the rat brain
dc.typeArticle
oaire.citation.volume91

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