HEPATOPROTECTIVE EFFECT OF NIGELLA SATIVA L. EXTRACT IN METHYL PARATHION EXPOSED RATS

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dc.authoridBerkoz, Mehmet/0000-0003-4219-8054
dc.contributor.authorBerkoz, Mehmet
dc.contributor.authorKahraman, Tahir
dc.contributor.authorYildirim, Metin
dc.contributor.authorYigit, Muhammet Faruk
dc.contributor.authorAllahverdiyev, Oruc
dc.date.accessioned2024-09-29T16:12:18Z
dc.date.available2024-09-29T16:12:18Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractMethyl parathion (MP) is an organophosphorus pesticide that can induce hepatotoxicity in living organisms. Although many plant extracts have been utilized againts MP induced liver injury, it has not yet known whether Nigella sativa L. extract (NSE) has protective effects or not. We aim to investigate the hepatoprotective effect of NSE through the oxidative stress and anti-inflammatory pathways. A total of 28 rats were divided into 4 groups; control, MP, NSE and MP + NSE. We measured liver MDA level and antioxidant parameters, hepatic function enzyme, plasma cytokine levels, liver MPO activity, liver iNOS and COX-2 mRNA levels and MAPK/NF-kappa b protein levels. Our data showed that MP increased hepatic function tests, liver MDA level and MPO activity, plasma proinflammatory cytokines, liver iNOS and COX-2 rnRNA and MAPKs protein levels and decreased antioxidant parameters, antiinflammatory cytokine and liver NF-kappa b protein levels. NSE decreased hepatic function tests, liver MDA level and MPO activity, plasma proinflammatory cytokines, liver iNOS and COX-2 mRNA and MAPKs protein levels and increased antioxidant parameters, anti-inflammatory cytokine and liver NF-kappa b protein levels in the MP treated rats. These results suggested the antiinflammatory and antioxidative function of NSE in MP induced liver injury.en_US
dc.identifier.endpage7087en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue10en_US
dc.identifier.startpage7079en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8666
dc.identifier.volume28en_US
dc.identifier.wosWOS:000487347700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethyl parathionen_US
dc.subjectNigella sativa L.en_US
dc.subjecthepatoprotectiveen_US
dc.subjectantioxidanten_US
dc.subjectantiinflammatoryen_US
dc.titleHEPATOPROTECTIVE EFFECT OF NIGELLA SATIVA L. EXTRACT IN METHYL PARATHION EXPOSED RATSen_US
dc.typeArticleen_US

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