Radiotherapy Induces Development of Fragmented QRS in Patients with Breast Cancer

Basit Öğe Kaydı
dc.authoridOnalan, Orhan/0000-0001-9780-7051
dc.authoridCanyilmaz, Emine/0000-0002-0736-1293
dc.contributor.authorAdar, Adem
dc.contributor.authorCanyilmaz, Emine
dc.contributor.authorKiris, Abdulkadir
dc.contributor.authorIlter, Abdulselam
dc.contributor.authorSerdar, Lasif
dc.contributor.authorMemis, Yahyahan
dc.contributor.authorBahat, Zumrut
dc.date.accessioned2024-09-29T16:04:53Z
dc.date.available2024-09-29T16:04:53Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Myocardial fibrosis is a well-known side effect of radiotherapy. Fragmented QRS (fQRS) has been shown to be a marker of myocardial fibrosis. We postulated that radiotherapy induces development of fQRS in breast cancer patients. Patients and Methods: Breast cancer patients receiving locoregional radiotherapy were enrolled. Patients who had fQRS on electrocardiography (ECG) before radiotherapy were excluded. All patients were revaluated for the development of fQRS at 1-year follow-up. An age-matched healthy group served as controls. Results: A total of 52 breast cancer patients receiving locoregional radiotherapy were included (median age 49 years, interquartile range (IQR) 13). Of these, 19 (37%) had developed fQRS at 1-year follow-up. Compared with the control group, prevalence of fQRS was significantly higher in the irradiated group (37 vs. 12%; p < 0.002). Median total cardiac radiation dose was significantly higher in patients who had developed fQRS (5 Gy, IQR 5.2 vs. 1.7 Gy, IQR 4.4; p = 0.003). Cardiac radiation dose, entered either as a continuous variable (odds ratio (OR) 1.35, 95% confidence interval (CI) 104-1.74) or as a dichotomized variable (>= 2.2 Gy, OR 6.48, 95% CI 1.47-28.61), was independently associated with the development of fQRS at 1-year follow-up. Conclusion: Radiotherapy for breast cancer induces development of fQRS on ECG. Cardiac radiation dose is independently associated with the development of fQRS.en_US
dc.identifier.doi10.1159/000431030
dc.identifier.endpage280en_US
dc.identifier.issn1661-3791
dc.identifier.issn1661-3805
dc.identifier.issue4en_US
dc.identifier.pmid26600765en_US
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.1159/000431030
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6387
dc.identifier.volume10en_US
dc.identifier.wosWOS:000361080300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofBreast Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFragmented QRSen_US
dc.subjectRadiotherapyen_US
dc.subjectBreast canceren_US
dc.titleRadiotherapy Induces Development of Fragmented QRS in Patients with Breast Canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu