Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection

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dc.authoridAcat, Murat/0000-0002-7163-4882
dc.contributor.authorAcat, Murat
dc.contributor.authorGulhan, Pinar Yildiz
dc.contributor.authorEroz, Recep
dc.contributor.authorErtinmaz Ozkan, Aysegul
dc.contributor.authorKoca, Oguzhan
dc.contributor.authorCinar, Caner
dc.date.accessioned2024-09-29T15:51:23Z
dc.date.available2024-09-29T15:51:23Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAimThe current study aimed to evaluate the effects of caspase-8 (CASP8) and mitogen-activated protein kinase 1 (MAPK1) gene expression levels and their products on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.MethodsA total of 40 patients (men, 15 [37.5%]; women, 25 [62.5%]) with COVID-19 infection were included in the current study. The patients were divided into four main groups based on disease severity: mild (n = 7), moderate (n = 10), severe (n = 14), and critical (n = 9). Individuals aged < 18 years and pregnant women were excluded. Patients were classified according to the World Health Organization (WHO) classification system (WHO/2019-nCoV/clinical/2021.1).ResultsConsidering all groups, statistically significant differences were detected among all groups for both CASP8(2-Delta Delta Ct) (p = 0.006) and MAPK1 2(-Delta Delta Ct) values (p = 0.015). Moreover, statistically significant differences were detected between mild and moderate (p = 0.013), moderate and critical (p = 0.018), and severe and critical (p = 0.023) groups for lymphocytes.ConclusionThe CASP8/MAPK1 expression levels and/or its products are essential in preventing injury caused by COVID-19 infection. They play crucial roles in maintaining cellular homeostasis and viability. Furthermore, CASP8/MAPK1 levels can provide information about disease severity.en_US
dc.description.sponsorshipKarabuk University coordinatorship of scientific research project [KBUEBAP-21-ABP-035]en_US
dc.description.sponsorshipThis study was supported by the Karabuk University coordinatorship of scientific research projects. (Project no: KBUEBAP-21-ABP-035)en_US
dc.identifier.doi10.1007/s11033-023-08244-4
dc.identifier.endpage3248en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue4en_US
dc.identifier.pmid36708447en_US
dc.identifier.startpage3241en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-023-08244-4
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4028
dc.identifier.volume50en_US
dc.identifier.wosWOS:000921163100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCASP8 geneen_US
dc.subjectCellular homeostasisen_US
dc.subjectMAPK1en_US
dc.subjectSARS-CoV-2en_US
dc.titleEvaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infectionen_US
dc.typeArticleen_US

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