Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reductase in Rats Exposed to Doxorubicin and Morin

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dc.authoridAGGUL, AHMET GOKHAN/0000-0003-0377-0388
dc.contributor.authorAggul, Ahmet Gokhan
dc.contributor.authorKuzu, Muslum
dc.contributor.authorKandemir, Fatih Mehmet
dc.contributor.authorKucukler, Sefa
dc.contributor.authorCaglayan, Cuneyt
dc.date.accessioned2024-09-29T16:08:00Z
dc.date.available2024-09-29T16:08:00Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjectives: Carbonic anhydrase (CA), 6-phosphogluconate dehydrogenase (6PGD) and thioredoxin reductase (TrxR) enzymes are the essential biological molecules needed for metabolic processes in all living cells. This study was designed to investigate the activities of CA, 6PGD and TrxR enzymes in the brain, kidney, liver, heart and testis tissues of the rats exposed to doxorubicin (DOX) and morin. Methods: Male Wistar albino rats were randomly divided into three groups as control, morin and DOX, each of them containing 7 rats. At the end of the experimental procedure, CA, 6PGD, and TrxR enzyme activities in tissues of rats were determined spectrophotometrically. Results: In our study, we observed that DOX activated CA enzyme in liver and kidney tissues while inhibiting CA enzyme in the other tissues, activated 6PGD enzyme in the kidney, liver and heart tissues, and inhibited the TrxR enzyme in all the tissues. In addition, morin activated CA enzyme in the liver tissue while inhibiting CA enzyme in the brain, heart and testis tissues. Morin activated 6PGD enzyme activity while it inhibited TrxR enzyme in all the tissues. Conclusion: The findings showed that doxorubicin and morin had similar properties in the tissues as to their effect on enzyme activities.en_US
dc.description.sponsorshipAgri Ibrahim Cecen University Scientific Research Projects Unit [ECZF.17.001]en_US
dc.description.sponsorshipA part of this research was supported by Agri Ibrahim Cecen University Scientific Research Projects Unit [Grant no ECZF.17.001].en_US
dc.identifier.doi10.33808/clinexphealthsci.632320
dc.identifier.endpage234en_US
dc.identifier.issn2459-1459
dc.identifier.issue3en_US
dc.identifier.startpage228en_US
dc.identifier.trdizinid471634en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.632320
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/471634
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7307
dc.identifier.volume10en_US
dc.identifier.wosWOS:000583482500008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectMorinen_US
dc.subjectCarbonic Anhydraseen_US
dc.subject6-phosphogluconate Dehydrogenaseen_US
dc.subjectThioredoxin Reductaseen_US
dc.titleAlterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reductase in Rats Exposed to Doxorubicin and Morinen_US
dc.typeArticleen_US

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