Antioxidant and ntiinflammatory efficacy of curcumin on lung tissue in rats with sepsis

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dc.contributor.authorAktas, Emel
dc.contributor.authorYildiran, Hilal
dc.date.accessioned2024-09-29T16:12:16Z
dc.date.available2024-09-29T16:12:16Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOBJECTIVE: To detect antioxidant and antiinflammatory efficacy of Curcumin (Cur) on lung tissue in rats with sepsis. METHODS: Totally 32 rats were divided into 4 groups; the rats in Group 1 (control group) had abdominal incision under sterile conditions following anesthesia and the abdomen was sutured. Abdominal incision was performed in the rats in Group 2 (Cur group) under sterile conditions following anesthesia and the abdomen was closed. Cur was given to this group after dissolving within dimethylsulphoxide as 100 mg/kg through oral gavage and started for 3 d before surgical procedure. Group 3 (CLP group) had caecal ligation and punction (CLP) under sterile conditions to create sepsis following anesthesia and the abdomen was sutured. CLP was performed in the rats in Group 4 (CLP + Cur group) under sterile conditions following anesthesia to create a sepsis model and the abdomen was closed. Cur was also given to this group after dissolving within dinnethylsulphoxide as 100 mg/kg through oral gavage and started for 3 d before surgical procedure. All the rats were sacrificed through blood aspiration from the heart under sterile conditions following anesthesia and lung tissues were removed after 24 h following the surgical procedures. The tissue samples were homogenizated for biochemical analyses; and nnalondialdehyde (MDA), nitric okxide (NO), myeloperoxidase (MPO), superoxidedysmutase (SOD) nd catalase (CAT) were analyzed through spectrophotometric method, immunhistochemical iNOS staining was performed to assess the inflammation; and histopathological differences between the groups were evaluated. RESULTS: A statistically significant decrease was detected in the CLP + Cur group when compared with the CLP group of which Cur was not given in terms of MDA, MPO and NO levels (P < 0.05) whereas a statistically significant elevation was found in the CLP + Cur group when compared with the CLP group in terms of SOD and CAT levels (P < 0.05). CONCLUSION: The study outcomes revealed that supplementation of Cur presents an antioxidant effect by reducing the free radical level and increasing the antioxidant enzyme levels; and an antiinflammatory effect by reducing iNOS level. (C) 2020 JTCM. All rights reserved.en_US
dc.identifier.endpage826en_US
dc.identifier.issn0255-2922
dc.identifier.issn1577-7014
dc.identifier.issue5en_US
dc.identifier.pmid33000583en_US
dc.identifier.startpage820en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8639
dc.identifier.volume40en_US
dc.identifier.wosWOS:000575823300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal Traditional Chinese Meden_US
dc.relation.ispartofJournal of Traditional Chinese Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectSepsisen_US
dc.subjectAnti-inflammatory agentsen_US
dc.subjectAntioxidantsen_US
dc.subjectNitric Oxide Synthase Type ITen_US
dc.titleAntioxidant and ntiinflammatory efficacy of curcumin on lung tissue in rats with sepsisen_US
dc.typeArticleen_US

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