Lack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Population

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dc.authoridALTUN, Adnan/0000-0002-1328-6349
dc.authoridBayri, Yasar/0000-0003-1707-6055
dc.contributor.authorBayri, Yasar
dc.contributor.authorTaskin, Emre
dc.contributor.authorUlus, Aykan
dc.contributor.authorBayrakli, Fatih
dc.contributor.authorAltun, Adnan
dc.contributor.authorBagci, Hasan
dc.date.accessioned2024-09-29T16:11:28Z
dc.date.available2024-09-29T16:11:28Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: The IL6 gene is related to several disease states. Its relation to aneurysm formation and aneurysmal SAH has been studied in the literature, but the reported results have not resulted in definite positive or negative data. In this study we aimed to examine IL6 gene polymorphisms in a Turkish population and further our understanding of the relationship. Results: We included 120 intracranial aneurysm SAH cases and 120 healthy controls to examine whether there was a genotype difference between these groups in the -174 G > C and -572 G > C promoter polymorphisms located in the IL6 gene. The differences between groups were studied using a chi-squared test. There was no statistical difference between aneurysmal SAH patients and controls for IL6 promoter 174G > C and 572G > C polymorphisms. Conclusions: IL6 promoter SNPs did not show a correlation with intracranial aneurysm formation and subarachnoid aneurysmal rupture in a Turkish population, but genetic differences between ethnic populations may give different results.en_US
dc.identifier.endpage292en_US
dc.identifier.issn1302-1664
dc.identifier.issue2en_US
dc.identifier.startpage288en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8452
dc.identifier.volume32en_US
dc.identifier.wosWOS:000361529400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntracranial aneurysmen_US
dc.subjectIL6 geneen_US
dc.subjectpolymorphismen_US
dc.subjectgenotypeen_US
dc.titleLack of Association Between Interleukin 6 Gene Promoter Polymorphisms and Aneurysmal Subarachnoid Hemorrhage in Turkish Populationen_US
dc.typeArticleen_US

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