Gender-dependent relationship between metabolic syndrome and homa-ir index in patients with impaired fasting glucose

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dc.contributor.authorÖzkan Sevencan, Nurhayat
dc.contributor.authorErtınmaz Özkan, Ayşegül
dc.date.accessioned2024-09-29T16:32:06Z
dc.date.available2024-09-29T16:32:06Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAim: This study aimed to assess whether metabolic syndrome (MetS) criteria varied by gender and whether the homeostatic model assessment of insulin resistance (HOMA-IR) index could be used as a new MetS predictor. Materials and Methods: We performed a standard oral glucose tolerance test (OGTT) in 316 patients with impaired fasting glucose (IFG) and investigated the presence of impaired glucose tolerance (IGT), type 2 diabetes mellitus (T2DM), and MetS. Results: We found that MetS was higher in females than males. The obesity rate was 57.0% and 36.8% for females and males, respectively. Of the patients who reached stage 3 obesity,13.4% were females and 0.9% were males. The HOMA-IR score was not an independent predictor for MetS. However, sensitivity was 91% and specificity was 100% for the cut-off value of HOMA-IR ? 2.38 in diabetic females with MetS. Abdominal obesity (91.2%), hyperglycemia (81.5%), hypertension (71.8%), hypertriglyceridemia (62.0%), and low high-density lipoprotein (HDL) (57.8%) were found in MetS patients. Conclusion: Abdominal obesity and impaired glucose metabolism are powerful predictors demonstrating the presence of MetS. Females are at greater risk than males for obesity, T2DM, and MetS. Although the HOMA-IR score is not a new MetS predictor, it may be an effective indicator of the combination of MetS and diabetes in females.en_US
dc.identifier.doi10.5455/annalsmedres.2020.05.518
dc.identifier.endpage416en_US
dc.identifier.issue2en_US
dc.identifier.startpage410en_US
dc.identifier.trdizinid429269en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.05.518
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/429269
dc.identifier.urihttps://hdl.handle.net/20.500.14619/11356
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleGender-dependent relationship between metabolic syndrome and homa-ir index in patients with impaired fasting glucoseen_US
dc.typeArticleen_US

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