THE IMPORTANCE OF ANTIOXIDANT STATUS IN GASTRIC INTESTINAL METAPLASIA

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dc.authoridDanis, Nilay/0000-0002-3939-3089
dc.contributor.authorDanis, Nilay
dc.contributor.authorOzkan, Aysegul
dc.contributor.authorKaratas, Fatih
dc.contributor.authorCakici, Cagri
dc.contributor.authorYigitbasi, Turkan
dc.contributor.authorSevencan, Nurhayat
dc.contributor.authorKayhan, Burcak
dc.date.accessioned2024-09-29T16:09:59Z
dc.date.available2024-09-29T16:09:59Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a difference between oxidative stress status in patients with intestinal metaplasia (IM) compared to individuals without IM, we compared the serum levels of disulfide (SS), total thiol (TT) and native thiol (NT). Methods: This was a prospective, non-randomized case-control study including 67 patients with histopathologically confirmed IM and 60 individuals demographically matched in terms of age, gender, BMI, smoking status, and chronic diseases as control group. Results: The mean NT, TT and NT to TT (NT/TT) ratios were statistically significantly higher in IM group compared to controls ((351.71 +/- 81.9 mu mol/L vs. 271.82 +/- 54.13 mu mol/L, p=0.000), (391.5 +/- 92.69 mu mol/L vs. 308.59 +/- 55.53 mu mol/L, p=0.000) and (0.89 +/- 0.6 vs. 0.87 +/- 0.29, p=0.022), respectively). The mean SS to TT (SS/TT) ratio was significantly lower in IM group than control group (0.050 +/- 0.31 vs. 0.060 +/- 0.014, P=0.022). Median SS and mean SS/NT ratio was similar in both groups (16.3 (3.3-78) vs. 18.3 (10-32.7), p=0.271 and 0.055 +/- 0.041 vs. 0.070 +/- 0.019, p=0.068, respectively). In ROC analysis, cut off value of SS/NT for IM was found 0.062, in regression analysis, SS/NT <0.062 was found as an independently prognostic marker for IM (OR, 2.38; 95%CI: 1.168-4.865, P=0.017). Conclusions: SS/NT ratio lower than 0.062 was found as an independently prognostic marker for IM. This ratio could help to distinguish which patients should be followed closely for gastric cancer.en_US
dc.identifier.doi10.5937/jomb0-29349
dc.identifier.endpage383en_US
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue4en_US
dc.identifier.pmid34616227en_US
dc.identifier.startpage378en_US
dc.identifier.urihttps://doi.org/10.5937/jomb0-29349
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7897
dc.identifier.volume40en_US
dc.identifier.wosWOS:000700885800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Medical Biochemists Serbiaen_US
dc.relation.ispartofJournal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntestinal metaplasiaen_US
dc.subjectoxidative stressen_US
dc.subjecttiolen_US
dc.subjectdisulphideen_US
dc.titleTHE IMPORTANCE OF ANTIOXIDANT STATUS IN GASTRIC INTESTINAL METAPLASIAen_US
dc.typeArticleen_US

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