INVESTIGATION OF DNA BINDING AND CLEAVAGE ACTIVITIES OF BORON COMPLEXES IN THE PRESENCE OF HYDROGEN PEROXIDE
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Babes-Bolyai
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)(2)](2)center dot 2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)(2)]center dot H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)(2)]center dot H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)(2)](2)center dot 10H(2)O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA.
Açıklama
Anahtar Kelimeler
Boron complexes, DNA-binding cleavage, DNA cleavage
Kaynak
Studia Universitatis Babes-Bolyai Chemia
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
59
Sayı
3
