Factors affecting survival in patients with isolated liver-metastatic colorectal cancer treated with local ablative or surgical treatments for liver metastasis

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dc.authoridSAKIN, Abdullah/0000-0003-2538-8569
dc.authoridSahin, Suleyman/0000-0001-9769-2565
dc.contributor.authorSakin, Abdullah
dc.contributor.authorSahin, Suleyman
dc.contributor.authorAtci, Muhammed Mustafa
dc.contributor.authorYasar, Nurgul
dc.contributor.authorGeredeli, Caglayan
dc.contributor.authorAribal, Serkan
dc.contributor.authorAlemdar, Ali
dc.date.accessioned2024-09-29T16:12:18Z
dc.date.available2024-09-29T16:12:18Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: Local treatments for isolated synchronous or metachronous liver metastases in colorectal cancer (CRC) have been shown to improve overall survival (OS). The aim of this study was to investigate the factors affecting OS in CRC patients with isolated liver metastasis in whom the primary tumor and corresponding liver metastasis were treated with curative intent using local ablative or surgical methods. Methods: A total of 47 CRC patients presenting with an initial or subsequent isolated liver metastasis, who were treated with local surgical or ablative treatment for liver metastasis with curative intent, were enrolled in this study between 2007 and 2017. The possible factors affecting OS were analyzed. Results: Out of the 47 patients, 35 (74.5%) were male. The median age was 61 (25-80) years. Thirty-four (72.3%) patients underwent liver metastasectomy, while 13 (27.7%) patients were treated with non-surgical local ablative therapies (NSLAT) for liver metastasis. Median OS (mOS) could not be reached in patients who underwent metastasectomy at the time of diagnosis compared to 55 months in those undergoing metastasectomy following a chemotherapy period (p=0.03). Patients treated with NSLAT had a mOS of 60 months compared to not reached'' in those who underwent liver metastasectomy (p=0.45). mOS was higher in patients with pT4 stage vs.en_US
dc.identifier.endpage1808en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue5en_US
dc.identifier.pmid31786840en_US
dc.identifier.startpage1801en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8667
dc.identifier.volume24en_US
dc.identifier.wosWOS:000501762000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcolorectal canceren_US
dc.subjectliver metastasisen_US
dc.subjectmetastasectomyen_US
dc.subjectsurvivalen_US
dc.subjectlocal ablative treatmentsen_US
dc.titleFactors affecting survival in patients with isolated liver-metastatic colorectal cancer treated with local ablative or surgical treatments for liver metastasisen_US
dc.typeArticleen_US

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