Investigation of associations between apolipoprotein A5 and C3 gene polymorphisms with plasma triglyceride and lipid levels

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dc.authoridTuran, Muhammed Kamil/0000-0002-1086-9514
dc.contributor.authorTaskin, Emre
dc.contributor.authorBagci, Hasan
dc.contributor.authorTuran, Muhammed Kamil
dc.date.accessioned2024-09-29T16:06:23Z
dc.date.available2024-09-29T16:06:23Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to determine frequency and associations between APOA5 c.56C>G, -1131T>C, c.553G>T, and APOC3-482C>T and SstI gene polymorphisms with hypertriglyceridemia. METHODS: Under a case-control study model, 135 hypertriglyceridemic and 178 normotriglyceridemic control participants were recruited. Polymerase chain reaction and restriction fragment length polymorphism methods were utilized for genotyping. Statistical calculations were performed by comparing allele and genotype frequencies between groups. Clinical characteristics were compared between groups and intra-group genotypes. RESULTS:APOC3 gene -482C>T and SstI polymorphic genotypes and allele frequencies were significantly higher in hypertriglyceridemic group (genotype frequencies, p=0.035, p=0.028, respectively). Regression analysis under unadjusted model confirmed that APOC3-482C>T and SstI polymorphisms were significantly contributing to have hypertriglyceridemia (p=0.02, odds ratio [OR]=1.831 (95% confidence interval [CI] 1.095-3.060); p=0.04, OR=1.812 (1.031-3.183), respectively).APOA5 c.56C>G was in complete linkage disequilibrium with APOA5 c.553G>T polymorphism (D'=1). CONCLUSION: For the first time in a population sample from Turkey, among the five polymorphisms of APOA5 and APOC3 genes investigated,APOC3-482C>T and SstI polymorphisms were associated with elevated serum TG levels, while APOA5 c.56C>G, -1131T>C, and c.553G>T polymorphisms were not.en_US
dc.identifier.doi10.1590/1806-9282.20221016
dc.identifier.endpage420en_US
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue3en_US
dc.identifier.pmid36921196en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20221016
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6809
dc.identifier.volume69en_US
dc.identifier.wosWOS:000992674300006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApolipoproteinen_US
dc.subjectA-Ven_US
dc.subjectApolipoprotein C-IIIen_US
dc.subjectLipidsen_US
dc.subjectApolipoproteinsen_US
dc.subjectGenetic variationen_US
dc.titleInvestigation of associations between apolipoprotein A5 and C3 gene polymorphisms with plasma triglyceride and lipid levelsen_US
dc.typeArticleen_US

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