Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease

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dc.authoridBenli, Ali Ramazan/0000-0003-0039-1497
dc.contributor.authorSevencan, Nurhayat Ozkan
dc.contributor.authorCesur, Ozkan
dc.contributor.authorCakar, Murat
dc.contributor.authorDogan, Erkan
dc.contributor.authorOzkan, Aysegul Ertinmaz
dc.contributor.authorBenli, Ali Ramazan
dc.date.accessioned2024-09-29T16:11:38Z
dc.date.available2024-09-29T16:11:38Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe aim of this study was to calculate the corrected rate of reflux in children with gastroesophageal reflux (GER)-like complaints by 24-hour pH monitoring and esophagogastroduodenoscopy (EGD), and to determine the utility of mean platelet volume (MPV) and red cell distribution width (RDW) as diagnostic biomarkers of GER disease (GERD) in children. The subjects in this prospective study were 109 children, 6 to 18 years old. Of them, 74 subjects were with GER symptoms and 35 healthy controls. The subjects were divided into three groups: those who underwent 24-hour pH monitoring (Group 1), those who underwent EGD together with pH monitoring (Group 2), and the healthy controls (Group 3). The results of pH monitoring and EGD and hematological parameters with controls were compared between Groups 1 and 2. In Groups 1 and 2, the overall rate of reflux was 40%, of esophagitis was 27.8%, and of Helicobacter pylori infection was 31.2%. The MPV and RDW cut-offs in subjects with reflux were <= 8.97 (sensitivity 89%, specificity 89%) and <= 12.78 (sensitivity 80%, specificity 97%), with an area under the Receiver Operating Characteristic (ROC) curve +/- standard error (AUC +/- SE) = 0.917 +/- 0.027 (P < 0.001) and AUC +/- SE = 0.866 +/- 0.036 (P < 0.001), respectively. The endoscopic procedures are not practical due to being invasive and expensive. However, hemogram is a simple test which can be performed in an outpatient clinic. MPV and RDW calculated in hemogram could be easy, cost-effective, and high sensitive new biomarkers that can be used in children with GERD.en_US
dc.identifier.endpage3186en_US
dc.identifier.issn1943-8141
dc.identifier.issue5en_US
dc.identifier.pmid31217887en_US
dc.identifier.startpage3176en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8594
dc.identifier.volume11en_US
dc.identifier.wosWOS:000469965000046en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofAmerican Journal of Translational Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastroesophageal reflux diseaseen_US
dc.subjectmean platelet volumeen_US
dc.subjectred cell distribution widthen_US
dc.subjectHelicobacter pylorien_US
dc.titleMean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux diseaseen_US
dc.typeArticleen_US

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