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Öğe Bromelain improved long-term erythema multiforme attacks induced by herpes simplex infection: a case report(2019) Aktaş, HabibullahErythema multiforme is an immune- mediated skin disorder characterized byerythematous target –like macules, papules and plaques commonly locatedover distal extremities as well as mucosal involvement. It is mostly inducedby herpes simplex infections and various medications. Recurrences of herpessimplex infections result in new erythema multiforme lesions in immunologicallysusceptible people. Therefore, suppressing herpes reactivations also suppresseserythema multiforme attacks. Antiviral medications such as acyclovir, valacyclovirand famciclovir have limited capacity to prevent such recurrences due totheir inadequate efficiency after continuous use . Those patients usually seekan absolute remedy to prevent recurrences. Bromelain is a well-known herbalsupplement containing proteolytic enzymes produced from pineapple plant. Ithas been used in many clinical conditions including sinusitis, sports injuries andneoplastic diseases for years with a great safety profile. Herein, we present ayoung female patient with long -term erythema multiforme attacks induced byherpes simplex infections. She became free of disease after using oralbromelain 500 mg twice a day for one year.Öğe Cancer is seen more in older female patients with psoriasis : a cross-sectional study in 1551 patients(2019) Aktaş, Habibullah; Serıfoglu, CansuAim: The aim of this study was to establish the potential risk of the development of malignancy in the patients with psoriasis.Material and Methods: A retrospective analysis of psoriasis cases between January 2017 to August 2018 attending the dermatologyclinic at Karabuk Research and Training Hospital was carried out. Patients with psoriasis were screened whether they have anymalignant disease and associated chronic disease including diabetes mellitus and hypertension by using hospital data system.Suspected cases regarding psoriasis or malignant disease were excluded. Findings were compared according to demographiccharacteristics of the patients.Results: A total of 1551 patients with psoriasis was evaluated in the study time. 30 patients (22 women, 8 men) were found to havemalignancy. The most commonly seen malignancy was stomach cancer in women and prostate cancer in men. 2% of patients withpsoriasis had cancer. This rate was 2.5% in female patients and 1% in male patients (p <0.005). The mean age of psoriatic patientswith cancer was 58.3 years , higher than 41.9 years which is the mean age of all psoriasis patients in the study (p <0.005). The cancercases were more common in psoriasis patients having diabetes and/or hypertension in comparison with those without diabetesand/or hypertesion (p <0.005).Conclusion: Cancer was found to be more common in female patients with psoriasis particularly in older age group. In addition,diabetes and hypertension have significant contribution to occurrence of the malignancy in patients with psoriasis.Öğe A case of cutaneous pseudolymphoma induced by medicinal leech application and review of the literature(2018) Aktaş, Habibullah; Hamıdı, Aziz Ahmad; Ertuğrul, Göksen; Erol, HarunMedicinal leech application is a common traditional therapy used for various disorders in many cultures for thousands of years. Although it is usually a safe method, serious side effects can also be seen. As a rare side effect of this method, cutaneous pseudolymphoma is a reactive skin disease caused by foreign antigens, infectious processes and arthropod bites. Idiopathic cases sometimes can be seen. In this article, we present a case of cutaneous pseudolymphoma in an elderly woman with multiple nodules over her lumbar region emerging after leech application.Öğe Changes in incidence and age distribution of scabies: a retrospective cohort study in a tertiary hospital(2019) Aktaş, HabibullahAim: Scabies is a pruritic skin disease caused by an ectoparasite named sarcoptes scabies var hominis. It sometimes makes endemics depending on lifestyles of communities. In this study, we point out that patients with scabies have increased in recent years. Methods: A retrospective review was carried out in the patients with scabies diagnosis between 2013January and 2018 July at the dermatology outpatient clinic of Karabuk Research and Training Hospital. The age and gender of the patients, and the season of diagnosis were recorded from the hospital database. Results: In this study, we found that the incidence of scabies increased from 0.4 % to 1% in the last 5 years in the dermatology outpatient clinic of our hospital (r=0,886 p=0.000). The mean age of scabies patients decreased from 49.7 to 31.4 within 5 years (r=-0,753 p=0,006). The female patients were much more than male patients (56% vs 44%), and their mean age was older than males (44 vs 37) (p=0,000). Conclusion: Scabies cases are increasing in number and the mean age of the patients is decreasing gradually at recent years.Öğe Combination therapy of shave excision, intralesional steroid injection, and topical imiquimod in the treatment of ear keloid(2019) Ertuğrul, Süha; Aktaş, Habibullah; Ertuğrul, GöksenKeloids are benign proliferative lesions caused byabnormal healing. Treatment of keloids is verydifficult due to high recurrence rates. In keloids, thereare many treatment modalities that can vary accordingto lesion size, localization, and previous interventions.A 17-year-old female patient presented with aposterior ear keloid that developed after pearcing intoher ear. The shaving excision was treated with a triplecombination consisting of single session intralesionalsteroid injection and daily topical imiquimodapplication for six weeks. Within one year, a verygood response was obtained without recurrence or anyside effect.Öğe Combination therapy of shave excision, intralesionalsteroid injection, and topical imiquimod in thetreatment of ear keloid(2019) Ertuğrul, Süha; Aktaş, Habibullah; Ertuğrul, GöksenKeloids are benign proliferative lesions caused byabnormalhealing.Treatmentofkeloidsisverydifficult due to high recurrence rates. In keloids, thereare many treatment modalities that can vary accordingto lesion size, localization, and previous interventions.A17-year-oldfemalepatientpresentedwithaposterior ear keloid that developed after pearcing intoher ear. The shaving excision was treated with a triplecombination consisting of single session intralesionalsteroidinjectionanddailytopicalimiquimodapplication for six weeks. Within one year, a verygood response was obtained without recurrence or anyside effect.Öğe Does bullous erythema ab igne develop easier in diabetics? A case series of four patients(2017) Benli, Ali Ramazan; Aydın, Ersin; Aktaş, Habibullah; An, İsaEritema ab igne kronik ısı maruziyetinin meydana getirdiği bir deri hastalığıdır. Özellikle alt ekstremitelerde subjektif belirtileri de olabilen ağ benzeri eritem ve pigmentasyonla kendini belli eder. Eritema ab igne malign potansiyeli nedeniyle önem taşır. Büllöz lezyonların eşlik ettiği eritem ab igne çok nadirdir ve şimdiye kadar diabetle ilişkisinden bahsedilmemiştir. Bu makalede büllöz eritema ab igne tanısı konulan dört diabetik hastayı sunuyor ve özellikle diabetik hastalarda kronik ısı maruziyetinin sakıncalarına vurgu yapıyoruz.Öğe Intralesional treatments in a dermatology outpatient clinic: analysis of one year(2018) Aktaş, Habibullah; Ertuğrul, GöksenObjective: It was aimed to show the range and application of intralesional drug treatment in a single dermatology outpatient department in this study. Material and Method: Patients who were treated intralesionally for any dermatological disease were retrospectively examined between January 2016 and January 2017. Intralesionally delivered agents, dermatological diseases and number of patients receiving therapy were noted. Results: The data of three hundred and forty-four patients were retrospectively analyzed. Twenty four different dermatological diseases were treated intralesionally with nine different agents. Of 344 patients, 179 (52 %) were male, 165 (48%) were female. Their average age was 34,5 years old. The most common indication for intralesional treatment during this period was alopecia areata consisting of 183 in number. Only one case of significant adverse effect was seen in a female patient who was treated for her oral lichen planus. Conclusion: It is shown that a dermatologist can overcome many challenging problems with this simple, easy and inexpensive method.Öğe Işitmenin etkilendiği relapsing polikondrit olgusu: nadir bir olgu(2021) Ertuğrul, Süha; Bayrak, Muhammed Harun; Söylemez, Emre; Ertuğrul, Göksen; Aktaş, HabibullahA CASE OF RELAPSING POLYCHONDRITIS IN\rWHICH HEARING IS AFFECTED: A RARE CASE\rRelapsing polychondritis, affecting the cartilage and\rconnective tissue of the ear, nose, tracheobronchial\rsystem; It is a rare disease characterized by chronic,\rautoimmune, episodic inflammatory attacks. In\raddition, proteoglycan-rich structures such as the eye,\rblood vessels, heart, and inner ear may be affected.\rWhile relapsing polychondritis has a progressive\rcourse in most patients, it may cause a shortened life\rexpectancy. Major clinical features are auricular and\rnasal chondritis, non-erosive arthritis, inflammatory\rinvolvement in the ophthalmic system, cartilage\rinvolvement in the respiratory system; dermatological,\rrenal, cardiac and audio-vestibular involvement. In this\rarticle, a 65-year-old male patient who was admitted to\rour ENT outpatient clinic with complaints of pain,\rswelling, redness, and hearing loss in both ears and\rdiagnosed with relapsing polychondritis is presented.Öğe Leukonychia is the most common nail change in alopecia areata patients: a retrospective study in 207 patients(2019) Aktaş, Habibullah; Ünal, MehmetAim: Alopecia areata is an auto-immune skin disease characterized by non-scarring hair loss. Nail changes are strongly associatedwith prognosis. In patients with Alopecia areata, the nail examination should not be neglected for an optimal follow-up.Material and Methods: A retrospective study involving 207 patients with Alopecia areata was undertaken in a tertiary hospitalbetween April 2016 and May 2017. Patients whose nail changes were registered in the database were included in the study. Gender,age, disease severity, sites affected, and nail changes of those patients were noted.Results: 114 patients (55%) had nail involvement. The most common nail finding was leukonychia (n = 84). Nail pitting was detectedin 29 patients.11 patients had both leukonychia and nail pitting. The mean age of the patients with leukonychia was 23.3, while themean age of nail pitting patients was 31.7 and the mean age of the patients without nail change was 34.1.Conclusion: Leukonychia is the most common nail change in this study, as a different finding from all previous studiesÖğe Omalizumab tahmin edilenden daha uzun remisyon sağlıyor: gözlemsel bir çalışma(2021) TürŞen, Belma; Aktaş, HabibullahAmaç: Omalizumab, antihistaminlere dirençli kronik ürtiker tedavisinde kullanılan monoklonal anti IgE antikorudur. Her dört haftada bir uygulama önerilmektedir. Yöntem: Kronik ürtiker tanısıyla izlenen 15 hastanın subkutan omalizumab tedavisine yanıtı yaş, cinsiyet, ürtiker süresi ve şiddetinin omalizumab ile elde edilen remisyon süresine etkisi incelendi. Bulgular: Yaş ortalaması 43.9±7.8 olan 8 kadın 7 erkek hastada ortalama 6.26±2.7 hafta remisyon sağlandı. Yaş, cinsiyet, ürtiker süre ve şiddeti remisyon süresini etkilemezken, ürtikerine astım eşlik eden hastalarda remisyon süresinin kısa olduğu gözlendi. Sonuç: Omalizumab dört hafta olarak belirlenen etki süresinden daha uzun remisyon sağlamaktadır.Öğe Onychomycosis and erectile dysfunction. Does common etiology cause togetherness?(2021) Baran, Özer; Aykaç, Aykut; Kaya, Coskun; Aktaş, HabibullahAim: We tried to determine the frequency of co-occurrence of erectile dysfunction (ED) and Onychomycosis (OM). Material and Methods: The sociodemographic form and IIEF-5 form were filled by the male patients who were admitted to the Urology Polyclinic of Karabük University Medical Faculty with the complaints of ED between April 2019 - April 2020. The patients with ED were included in the study. All the male patients were divided into three groups as mild, moderate and severe according to ED severity. The dermatologist (H.A) examined the presence of OM by taking samples from the toenails of the male patients. Results: Looking at the IIEF-5 scores of 95 patients accepted to the study, it was found that 22 (23.1%) had mild, 20 (21%) moderate and 53 (55.9%) severe ED. Smoking history was higher in the severe ED group (p <0.001). It was found that a total of 32 (33.7%) patients had OM. However, there was no relationship between the severity of ED and the presence of OM (p> 0.114). Conclusion: Erectile dysfunction and OM disease can often be seen together. However, no relationship was found with the severity of ED.Öğe A retrospective analysis on the concomitance of seborrheic dermatitis and fatty liver disease(2019) Aktaş, Habibullah; Öner, Serkan; Cebecık, AybalaThe present study aimed to investigate the correlation between seborrheic dermatitis and fatty liver disease and to determine the impact of age, gender, and concomitant chronic diseases. The present study sample included 120 (18-65 years old) patients who were diagnosed with seborrheic dermatitis between January 2018 and December 2018 and underwent upper abdominal ultrasonography. The demographic patient data, the liver fatty tissue rate in ultrasonography reports and the presence of other concomitant diseases were analyzed in the present retrospective study. The mean age of 52 male and 68 female patients was 45.5 ± 17.2. A total of 47 (39.2%) patients had hepatic steatosis. Hepatic steatosis rate was 52% in male patients and 29.4% in female patients. The mean age of the patients with hepatic steatosis was 54.8 ± 12.7, and the mean age of the patients with normal liver findings was 38.7 ± 17.2 (p <0.05). The number of patients with other concomitant chronic disease and seborrheic dermatitis was 56 (46.6%), and common concomitant diseases included hypertension (17.5%), diabetes (11.6%), hypothyroidism (7.5%) and hyperlipidemia (5%). Fatty liver disease was diagnosed in 59% of the patients with a comorbid disease, and this rate was 22% in the group without a comorbid disease (p <0.05). In patients with seborrheic dermatitis, as the age progressed and other internal diseases accompanied the disease, the likelihood of hepatic steatosis increased. Furthermore, hepatic steatosis was more common among male seborrheic dermatitis patients.Öğe Sağmaç nodülü(2016) Aktaş, Habibullah; Ertuğrul, Gökçen; Ergın, CanSağmaç nodülü (sütçü nodülü) pox virüs ailesinden parapox virüslerin neden olduğu, benign seyirli bir deri hastalığıdır. Virüs genellikle enfekte ineklerin memelerinden süt sağma sırasında bulaşmakla beraber, hastalıklı sığırların diğer vücut bölgelerine ya da kontamine materyallerle temas ile de bulaşabilmektedir. Hastalık genelde kendi kendini sınırlar ve benign seyirlidir ancak çok daha tehlikeli olan deri şarbonundan ayrımı önemlidir. Bu nedenle biz burada 44 yaşında sütçü nodülü olan bir kadın hasta sunduk.
