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Öğe Can YouTube English Videos Be Recommended as an Accurate Source for Learning About Testicular Self-examination?(Elsevier Science Inc, 2020) Selvi, Ismail; Baydilli, Numan; Akinsal, Emre CanOBJECTIVE To evaluate the content, reliability and quality of the most viewed YouTube videos related to testicular self-examination. METHODS The terms testicular self-examination, testis examination, and testis exam were used to search YouTube videos. Of 300 videos, a total of 123 videos were included. They were divided into 2 groups according to accuracy: useful information (Group 1, n = 78, 63.4%) and misleading information (Group 2, n = 45, 36.6%). A 5-point modified DISCERN tool was used to assess the reliability, a 5-point Global Quality Score was used to evaluate the quality, and a 7-point scale was used to assess the comprehensiveness of the videos. RESULTS DISCERN score (median 3, IQR: 3-4 vs median 1, IQR: 0-2, P < .001), Global Quality Score (median 4, IQR: 4-5 vs median 1, IQR: 1-2, P < .001), and comprehensiveness score (median 6, IQR: 5-6 vs median 1, IQR: 0-2, P < .001) were higher in Group 1. This group also had higher numbers in terms of total views, views per day and likes. It was seen that universities/professional organizations/nonprofit physician/physician groups (23.1%), stand-alone health information websites (21.8%), and testicular cancer survivors (28.2%) uploaded most of the videos in Group 1, whereas the majority in Group 2 were individual users (68.9%). CONCLUSION We observed that YouTube videos are of high quality, reliability, and rich content in terms of all of the steps related to how testicular self-examination should be done. However, since the YouTube search algorithm is not actually sufficient enough, it is not easy and practical for a lay man to find a suitable video by searching for keyword in the YouTube list. (C) 2020 Elsevier Inc.Öğe The Effect of Cardiovascular Morbidity on Clinical Responsiveness to Anticholinergics in Postmenopausal Women With Urge Urinary Incontinence(Elsevier Science Inc, 2021) Selvi, Ismail; Baydilli, Numan; Arik, Ali Ihsan; Basar, HalilOBJECTIVE To evaluate whether there is an association between severity of cardiovascular morbidity and urge urinary incontinence (UUI), and to assess the clinical responses of postmenopausal female patients in different cardiovascular risk groups to anticholinergics. METHODS A total of 220 postmenopausal female patients aged 43-70 years old with overactive bladder with UUI between December 2019 and July 2020 were included. They were divided into 3 groups according to the Framingham risk score that calculates the 10-year risk of cardiovascular disease development: low-risk (n: 90, 40.9%), intermediate-risk (n: 47, 21.3%), and high-risk (n: 83, 37.8%).Their demographic and clinical data were recorded. The intensity of UUI and its effect on quality of life (QoL) were evaluated at admission, 8th week and 16th week of anticholinergic therapy. RESULTS At admission attendance, BMI, smoking rate, presence of hypertension and diabetes mellitus, total cholesterol level and severity of UUI were higher in the high-risk group, whereas HDL level was lower and the effect of UUI on QoL was worse (P<.001). At the 16-week follow-up the improvement of UUI severity and QoL was significantly more pronounced in the low-risk and intermediate-risk groups (P<.001).The highest daily-dryness rates were observed in the low-risk group (65.6%), while the highest rates for refractory overactive bladder (OAB) were seen in the high-risk group (19.3%). CONCLUSION Our findings show that more severe UUI and more impaired QoL is observed in high-risk patients for cardiovascular morbidity. Individualized treatment may be important in the high-risk group since they may benefit less from anticholinergics and refractory OAB can be more common. (C) 2020 Elsevier Inc.Öğe How does body mass index affect semen parameters and reproductive hormones in infertile males?(Aves, 2020) Baydilli, Numan; Selvi, Ismail; Akinsal, Emre Can; Zararsiz, Gozde Erturk; Ekmekcioglu, OguzObjective: The aim of this study was to invastigate the effect of body mass index (BMI) on semen parameters and reproductive hormone levels in infertile males. Material and methods: Overall, 858 infertile male patients, aged between 18 and 55 years, referred to our infertility clinic were included in the study. Patients without risk factors, besides obesity, that could affect semen parameters or reproductive hormones were evaluated. Patients were separated into the following three groups: non-obese (<25 kg/m(2)), overweight (25-29.9 kg/m(2)), and obese (>= 30 kg/m(2)). Age, semen parameters, and reproductive hormones were evaluated and compared among the groups. In addition, subgroups based on sperm concentration were compared. Results: Total testosterone and testosterone-estradiol ratio negatively correlated with BMI (p<0.001). A positive correlation was observed between BMI and age (p<0.001). Even when adjusted for age, the decrease in total testosterone was significant in all groups parallel to the increase in BMI. Although age, prolactin level, and total testosterone had a significant relationship in univariate analysis, the only significant parameters were prolactin and total testosterone according to multivariate analysis. There were no significant differences between BMI and semen parameters. No significant difference related to BMI was observed among the infertile groups [severe oligospermia (34.3%), oligospermia (18.2%), and normospermia (47.6%)]. Conclusion: A significant negative correlation was observed between increasing BMI and total testosterone, No relationship was observed between BMI and semen parameters except progressive motility. Nevertheless, prospective longitudinal clinical trials with larger sample sizes involving weight loss are needed to understand the precise relationship of BMI with reproductive hormones and semen parameters in the same individual.Öğe The importance of plasma arginine level and its downstream metabolites in diagnosing prostate cancer(Springer, 2019) Selvi, Ismail; Basar, Halil; Baydilli, Numan; Murat, Koza; Kaymaz, OzlemPurpose There is still no certain threshold value of prostate-specific antigen (PSA) for prostate cancer diagnosis. We aimed to investigate the predictive value of arginine and its metabolites for diagnosing prostate cancer in patients with PSA 4-10 ng/ml and evaluate their usefulness as prognostic tumor markers. Methods Seventy-eight patients with a mean age of 64.505.49 years were included in our prospective observational study between November 2016 and March 2017. They were divided into two equal groups according to the pathologic results of prostate biopsy (benign vs. malignant). Plasma arginine and ornithine levels were analyzed before biopsy by liquid chromatography-tandem mass spectrometry. ELISA was used for analyzing urinary diacetylspermine. Results In PSA-adjusted analysis, the malignant group had lower plasma arginine levels (p=0.021) and arginine to ornithine ratio (AOR) (p=0.010), but higher plasma ornithine levels (p=0.012) and urinary diacetylspermine levels (p<0.001) as compared with the benign group. While arginine (r=-0.628, p<0.001) and AOR (r=-0.714, p<0.001) were negatively correlated with D'Amico clinical classification (p<0.001), ornithine (r=0.659, p<0.001) and diacetylspermine (r=0.710, p<0.001) were found to be positively correlated (p<0.001). In multivariate analysis, ornithine [OR 3.264, 95% CI (1.045-10.196), p=0.042] and diacetylspermine [OR 6.982, 95% CI (2.403-20.290), p<0.001] were found to be more significant in detection of prostate cancer. Conclusion Plasma arginine, ornithine, AOR and urinary diacetylspermine levels may be used as molecular markers to predict prostate biopsy outcomes in patients with PSA 4-10 ng/ml. But according to our results, the use of ornithine and diacethylspermine prior to biopsy seems to be the most cost-effective diagnostic strategy.Öğe Reappraisal of the Definition Criteria for Genitourinary Syndrome of Menopause, and its Effect on Quality of Life in Turkish Postmenopausal Women(Elsevier Science Inc, 2020) Selvi, Ismail; Baydilli, Numan; Yuksel, Dilek; Akinsal, Emre Can; Basar, HalilOBJECTIVE To reappraise the definition of Genitourinary syndrome of menopause (GSM) and to evaluate the prevalence and effect of GSM on quality of life in Turkish postmenopausal women. METHODS A multicenter, cross-sectional, and observational study was designed. Four hundred three postmenopausal women between the ages of 43-75 who attended Urology and Gynecology clinics between November 2019 and April 2020 were included.They were divided into 2 groups: Group I (GSM, n:288, 71.5%) and Group II (non-GSM, n:115, 28.5%). Demographic data, presence and intensity of genitourinary symptoms were recorded. The impact of menopause and urinary incontinence on quality of life was evaluated with the Menopause-Specific Quality of Life Questionnaire and the King's Health Questionnaire. RESULTS The most common symptoms were vaginal dryness (66.2%), reduced lubrication (55.3%), and urgency (54.8%). Urinary incontinence was present in 39.2% of women. Worse quality of life in terms of psychosocial and sexual domains of the Menopause-Specific Quality of Life Questionnaire was significant in Group 1 (P < .001). Group 1 had significantly worse scores for all domains of the King's Health Questionnaire. Only the rate of patients with stress incontinence was higher in Group 1. However, the percentage of moderate and severe symptoms for all types of incontinence was higher in Group 1. Although the prevalence of GSM was 71.5% according to our definition, the percentage of patients previously visiting healthcare professionals for their symptoms was low (52.8%). CONCLUSION Our findings show that urologists and gynecologists should question both symptom groups of postmenopausal women, even if patients do not bring up genitourinary symptoms. UROLOGY 144: 83-91, 2020. (c) 2020 Elsevier Inc.
