The importance of plasma arginine level and its downstream metabolites in diagnosing prostate cancer
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose There is still no certain threshold value of prostate-specific antigen (PSA) for prostate cancer diagnosis. We aimed to investigate the predictive value of arginine and its metabolites for diagnosing prostate cancer in patients with PSA 4-10 ng/ml and evaluate their usefulness as prognostic tumor markers. Methods Seventy-eight patients with a mean age of 64.505.49 years were included in our prospective observational study between November 2016 and March 2017. They were divided into two equal groups according to the pathologic results of prostate biopsy (benign vs. malignant). Plasma arginine and ornithine levels were analyzed before biopsy by liquid chromatography-tandem mass spectrometry. ELISA was used for analyzing urinary diacetylspermine. Results In PSA-adjusted analysis, the malignant group had lower plasma arginine levels (p=0.021) and arginine to ornithine ratio (AOR) (p=0.010), but higher plasma ornithine levels (p=0.012) and urinary diacetylspermine levels (p<0.001) as compared with the benign group. While arginine (r=-0.628, p<0.001) and AOR (r=-0.714, p<0.001) were negatively correlated with D'Amico clinical classification (p<0.001), ornithine (r=0.659, p<0.001) and diacetylspermine (r=0.710, p<0.001) were found to be positively correlated (p<0.001). In multivariate analysis, ornithine [OR 3.264, 95% CI (1.045-10.196), p=0.042] and diacetylspermine [OR 6.982, 95% CI (2.403-20.290), p<0.001] were found to be more significant in detection of prostate cancer. Conclusion Plasma arginine, ornithine, AOR and urinary diacetylspermine levels may be used as molecular markers to predict prostate biopsy outcomes in patients with PSA 4-10 ng/ml. But according to our results, the use of ornithine and diacethylspermine prior to biopsy seems to be the most cost-effective diagnostic strategy.
Açıklama
Anahtar Kelimeler
Arginine, Diacetylspermin, Ornithine, Prostate biopsy, Prostate cancer, Tumor marker
Kaynak
International Urology and Nephrology
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
51
Sayı
11
