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    Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats
    (Churchill Livingstone, 2023) Demir, M.; Altinoz, E.; Koca, O.; Elbe, H.; Onal, M. O.; Bicer, Y.; Karayakali, M.
    Doxorubicin (DXR) is widely used in cancer treatment. However, it has not yet been possible to prevent the side effects of DXR. The aim of this study was to investigate the hepatoprotective effect of crocin against DXR used in cancer treatment. For this reason; forty Wistar rats (male-250-300 g) were allocated into four groups (n = 10/ group): Control, Crocin, DXR and DXR+Crocin. Control and Crocin groups were administered saline and crocin (40 mg/kg, i.p) for 15 days, respectively. DXR group, cumulative dose 12 mg/kg DXR, was administered for 12 days via 48 h intervals in six injections (2 mg/kg each, i.p). DXR+Crocin group, crocin (40 mg/kg-i.p) was administered for 15 days, and DXR was given as in the DXR group. The results revealed that serum liver markers (alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) increased significantly after DXR administration but recovered after crocin therapy. In addition, lipid peroxidation (MDA), and inflammatory cytokine (TNF-& alpha;) increased after DXR application and the antioxidative defense system (GSH, SOD, CAT) significantly decreased and re-achieved by crocin treatment. Our results conclude that crocin treatment was related to ameliorated hepatocellular architecture and reduced hepatic oxidative stress and inflammation in rats with DXR-induced hepatotoxicity.
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    Cryptotanshinone Protects Against Acute Pulmonary Edema
    (Istanbul University Press, 2023) Yilmaz, U.; Demir, M.
    Objective: Cryptotanshinone (CTS) is a compound with anti-inflammatory, anti-bacterial, anti-oxidative and anti-aggregant functions. We aimed to determine the effects of CTS on ?-naphtilthiourea (ANTU)-induced acute pulmonary edema. Materials and Methods: In this study, 4 groups (control, sham, ANTU and ANTU+CTS) were established from a total of 40 rats. The ANTU+CTS group received intraperitoneal CTS for seven days, and both ANTU and ANTU+CTS received an ANTU administration for the induction of peripheral effusion. Four hours after the ANTU administration, the rats were subjected to a forced swim test and were decapitated. Swimming times of rats, amount of pleural effusion (PE), lung weight (LW)/body weight (BW), and PE/BW ratios were determined. Results: At the end of the experiment, PE was not detected in the lungs of control and sham group rats. It was determined that PE, LW/ BW and PE/BW were significantly decreased, while swimming time was increased after acute pulmonary edema in the CTS group (p<0.05). Conclusion: CTS showed a protective effect against acute pulmonary edema, which indicates that it may be used as a new therapeutic agent against pulmonary toxicity. © 2023, Istanbul University Press. All rights reserved.