Cryptotanshinone Protects Against Acute Pulmonary Edema
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Istanbul University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Cryptotanshinone (CTS) is a compound with anti-inflammatory, anti-bacterial, anti-oxidative and anti-aggregant functions. We aimed to determine the effects of CTS on ?-naphtilthiourea (ANTU)-induced acute pulmonary edema. Materials and Methods: In this study, 4 groups (control, sham, ANTU and ANTU+CTS) were established from a total of 40 rats. The ANTU+CTS group received intraperitoneal CTS for seven days, and both ANTU and ANTU+CTS received an ANTU administration for the induction of peripheral effusion. Four hours after the ANTU administration, the rats were subjected to a forced swim test and were decapitated. Swimming times of rats, amount of pleural effusion (PE), lung weight (LW)/body weight (BW), and PE/BW ratios were determined. Results: At the end of the experiment, PE was not detected in the lungs of control and sham group rats. It was determined that PE, LW/ BW and PE/BW were significantly decreased, while swimming time was increased after acute pulmonary edema in the CTS group (p<0.05). Conclusion: CTS showed a protective effect against acute pulmonary edema, which indicates that it may be used as a new therapeutic agent against pulmonary toxicity. © 2023, Istanbul University Press. All rights reserved.
Açıklama
Anahtar Kelimeler
Cryptotanshinone, ?-naphthylthiourea, pleural effusion, pulmonary edema, swimming duration
Kaynak
Experimed
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
13
Sayı
2