Cryptotanshinone Protects Against Acute Pulmonary Edema

Küçük Resim Yok

Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Istanbul University Press

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Objective: Cryptotanshinone (CTS) is a compound with anti-inflammatory, anti-bacterial, anti-oxidative and anti-aggregant functions. We aimed to determine the effects of CTS on ?-naphtilthiourea (ANTU)-induced acute pulmonary edema. Materials and Methods: In this study, 4 groups (control, sham, ANTU and ANTU+CTS) were established from a total of 40 rats. The ANTU+CTS group received intraperitoneal CTS for seven days, and both ANTU and ANTU+CTS received an ANTU administration for the induction of peripheral effusion. Four hours after the ANTU administration, the rats were subjected to a forced swim test and were decapitated. Swimming times of rats, amount of pleural effusion (PE), lung weight (LW)/body weight (BW), and PE/BW ratios were determined. Results: At the end of the experiment, PE was not detected in the lungs of control and sham group rats. It was determined that PE, LW/ BW and PE/BW were significantly decreased, while swimming time was increased after acute pulmonary edema in the CTS group (p<0.05). Conclusion: CTS showed a protective effect against acute pulmonary edema, which indicates that it may be used as a new therapeutic agent against pulmonary toxicity. © 2023, Istanbul University Press. All rights reserved.

Açıklama

Anahtar Kelimeler

Cryptotanshinone, ?-naphthylthiourea, pleural effusion, pulmonary edema, swimming duration

Kaynak

Experimed

WoS Q Değeri

Scopus Q Değeri

N/A

Cilt

13

Sayı

2

Künye